The Expression Of P-VEGFR,P-PDGFR In Hippocampus Of Rabbits With Chronic Intermittent Hypoxia And Study The Change Of The Expression Intervened By Atorvastatin

AbjectiveTo explore the expression of P-VEGFR,p-PDGFR mRNA and proteinic level in hippocampus of rabbit with chronic intermittent hypoxia(CIH),and analyse its clinical significance..SettingAnimal lab,Department of Zoopery,Second Xiangya Hospital, Central South University,Changsha,China.ParticipantsTwenty-four healthy New Zealand rabbits all at the age of seven months,male.Methodstwenty-four male rabbits were divided into four groups:A group was a blank contrast group;B group was treated by 8-week intermittent hypoxia and 4-week pause;C group was treated by 12-week intermittent hypoxia and intervened by atorvastatin during the later 4 weeks;D group was treated by 12-week intermittent hypoxia.Western Blot was used to examine the expression of phosphorylation vascular endothelial growth factor receptor(P-VEGFR)and phosphorylation platelet- derived growth factor receptor(p-PDGFR)proteinic level in the hippocampus of rabbits in each group.Reverse transcriptase polymerase chain reaction(RT-PCR) was used to measure the expression of VEGFR and PDGFR mRNA。ResultsThe expression of P-VEGFR p-PDGFR mRNA and proteinic level in A group significantly lower than those in B,C and D group(P＜0.05). The mRNA and proteinic level of P-VEGFR p-PDGFR in D group was significantly higher than those in B group(P＜0.05),as well as C group(P＜0.05).There was no significant difference between B group and C group in the expression of P-VEGFR p-PDGFR(P＞0.05).Conclusions1,It suggested that trauma of brain tissue caused by CIH can enhance the expression of P-VEGFR and P-PDGFR in hippocampus of rabbits;2,It suggested that atorvastatin may be of somewhat protection for hippocampus impairment of rabbits caused by chronic intermittent hypoxia..