Epidemiologic Study And Pathogenic Candida Species Research On Pregnancy And Vulvovaginal Candidiasis

Objective:The aim of this study is to evaluate the clinical features,risk factors and Pathogenic Candida species in pregnancy and vvlvovaginal candidiasis.As well as analysis antifungal sensitivity in vulvovaginal candidial strains.PartⅠ:Study on the Clinical features and Risk Factors in Vulvovaginal CandidiasisMethods and Design:The present study was designed as an observational controlled study.294 pregnancy woman from July15th 2007 to Jan30th 2004 in Tianjin Obstetricis& Gynecology Hospitle were divided into two groups:Case group including 196 pregnancy woman with positive-culture for fungi.Control group consist of 98 patients whose culture for fungi were negative.Unconditional logistic regretssion model and Nonparametric test were used for analysis.Result:1.The highest prevalence of was found in women aged between 21-29 years.The mean age of vulvovaginal candidasis was 28.51±4.22.190 of 294 pregnency weman who have vaginitis present symptoms totrouble VVC,the account is 66.67% (196/294).2.Symptoms and Signs:Vulvar pruritus,engorgement,pain during intercourse was more significantly in pregnancy and VVC.3.The following factors were associated with VVC:Risk factor:VVC history;infection of husband's genital;parity;protective pad;clysis of vagina before pregnancy;not washing hands before going to the washroom;not exchange the pants diligently;to wipe from back to front before excrement;oral sexual habits;passive smoking;never use condom;gravidity.Protect factor:often have acidophilous milk;physical exercise.4.VVC is associated with a normal vaginal PH(＜-4.5),PH elevated＞4.5 usually indicate mixed infections occur.Microscopic examination of the discharge: found differentce in smear method and 10%potassium hydroxide respectively.PartⅡ:A Study on Pathogenic Candida species and antifungal sensitivity in Vulvovaginal candidiasis Methods and Design:According to the difference of the yeast fungus,196 patients both with vaginal symptoms and coulture-positive for fungi were seprate into two set,and identification Pathogenic Candida species;and analysis antifungal sensitivity in the Candida species.Result:1.Candida albicans was still the most commonly identified species of pathogenic parasilosis yeasts account for 95.41%(187/196).Non-albicans 4.59% (9/196),the most prevalent species of the non-albicans was tropicalis species,account for2.55%(5/196).2.We found Non-albicans species of clinical isolates to be different in susceptible to several antifungals in vitro as compared to C.albicans strains,espatialy in Clotrimazo land emiconazole.3.The antifungal sensitivity and pathogenic Candida species was no difference in patients with or without a history of VVC.No high number ofresistant strains was observed for azole antifungals.Conclusion:1.190 of 294 pregnency weman who have vaginitis present symptoms totrouble VVC,the account is 66.67%(196/294).2.Symptoms and Signs:Vulvar pruritus,engorgement,pain during intercourse was more significantly in pregnancy and VVC.3.The following Risk factors associated with VVC:VVC history;infection of husband's genital;parity;protective pad;clysis of vagina before pregnancy;not washing hands before going to the washroom;not exchange the pants diligently;to wipe from back to front before excrement;oral sexual habits;passive smoking;never use condom;gravidity.Protect factor:often have acidophilous milk;physical exercise.4.VVC is associated with a normal vaginal PH(＜-4.5).Smear method is more economy and quickly.5.Candida albicans was still the most commonly identified species of pathogenic parasilosis yeasts account for 95.41%(187/196).Non-albicans 4.59%(9/196),the most prevalent species of the non-albicans was tropicalis species,account for2.55 %(5/196).We found Non-albicans species of clinical isolates to be different in susceptible to several antifungals in vitro as compared to C.albicans strains,espatialy in Clotrimazo land emiconazole.The antifungal sensitivity and pathogenic Candida species was no difference in patients with or without a history of VVC.No high number ofresistant strains was observed for azole antifungals.