| The biodegradable polymer materials have been widely investigated and applied in material science and biomedical field in recent years. Poly(L-lactic acid) has been attached much attention in biomaterial applications owing to its safety, biodegradability, environmental compatibility and so on. However, its clinical applications are sometimes interfered with hydrophobic property, which could decrease the biocompatibility. Poly(ethylene glycol) is also an excellent biomaterial with hydrophilic ability, biocompatibility and resistibility to protein adsorption and cell adhesion. PLLA is usually modified by PEG to get a better material, which could combine the advantages of PLLA and PEG.In the paper, multi-hydroxyl groups ended poly(L-lactic acid)s (PLLA-OH) were prepared using L-lactic acid and 1, 6-hexanediol / 2-ethyl-2-hydroxymethyl-1, 3-propanediol / pentaerythritol by direct polycondensation. Afterward, acrylated poly (L-lactic acid)s (PLLA-AC) were gained through the reaction of PLLA-OHs and acryloyl chloride. Furthermore, a series of PLLA-PEG hydrogel films were formed by UV photopolymerization using 2, 2-dimethoxy-2-phenylacetophenone (DMPA) as initiator.The structures and properties of PLLA-OHs and PLLA-ACs were characterized by IR, 1H-NMR, GPC and XRD. The properties of PLLA-PEG hydrogel films were measured by XRD, SEM and so on. Besides, the swelling performance, degradation and drug release behaviors of PLLA-PEG hydrogel films were also studied in detail.The results show that PLLA-PEG hydrogel films could improve the property and performance by changing PLLA-AC molecular weight, structure and proportion of PEG-DA, which could be widely applied in biomedical field in the future.
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