The New Temperature The Sensitivity Pepn Biological Materials And Its Nano-drug Delivery Systems Research

The Research on Novel Temperature-responsive PEPN Series Biomaterials and Its Polymeric Nanoparticles Application on the Drug Delivery System: the Investigation of Synthesis and Characterizations of Temperature-responsive Copolymer of PELGA Modified N-isopropylacrylamide, the in vitro Release Profile, Stability In Water. Cytotoxicity and Acute Toxicity of Polymeric Nanoparticles.People suffered from cancer and rheumatoid arthritis (RA), it is a great adventure to elevate the therapy index.Poly(N-isopropylacrylamide)(PNIPAAm) is special hydrogel which displays lower critical solution temperature(LCST) in water. The homogenous PNIPAAm structure swells when outer temperature low than LCST while contracts at that of high. Poly(lactic acid)-co-poly-(glycolic acid)(PLGA) and poly(ethylene glycol)(PEG) are the a few materials approved for inject purpose by FDA, which have hydrophobic characters in PLGA with certain molecular weight. Through covalent bond, PLGA, methoxyPEG (mPEG) and PNIPAAm are combined together with poly(N-hydromethylacryl- amide) (PNHMAAm) adjusting the LCST. The temperature- responsive copolymer can be self-assembled in water whose hydrophilic segments stretch into outer atmosphere while hydrophobic partments consist as inner core. Because of the hydrophilic outer shell, the nanoparticles can be ignored by RES system and displays character of long-time circulation in blood.Novel amphiphilic PELGA modified temperature-responsive copolymer, [(poly (methoxyethylene glycol)-co-poly(lactic acid)-co- poly-(glycolic acid)) acrylate]-co- poly(N-isopropylacrylamide)-co-poly(N-hydroxymethylacryl- amide)]...