Clinical Analyses Of 85 Cases Of Gynecologic Malignant Tumor In Young Women

Objective: To investigate gynecological tumor incidence, clinical characteristics, treatment, the histological types of the tumor and the significance of retaining reproductive function and ovarian function in women aged 10-30 years old.Methods: To retrospective analysis and summary medical records, age, onset age, pathology nature of tumor, staging, treatment, and other clinical data in women 10-30 years old, which are from 1997-2006 in Qilu Hospital, Shandong University.Results: During 10 years in Qilu Hospital of Shandong University, patients aged 10-30 year old are 85 cases, with gynecological malignant tumor. The average age is 25.2 years old, and a median age is 26 years old. Cervical cancer is 21 cases, endometrial cancer is 6 cases, the uterus choriocarcinoma is 9 cases, vulvar cancer is 2 cases, and 43 cases are ovarian cancer; The most common primary site is the ovary, and the total patients are 43 cases (51%).The second is uteri cervix, the total patients are 21 cases (25%); The incidence of gynecologic malignancies increases with the age growing. During ovarian malignant tumor, the OGCT is capital, but it lacks specificity of clinical manifestations. The main clinical manifestations of cervical cancer are contacting bleeding and menstrual disorder. The squamous cell carcinoma is 71.4%, and the adenocarcinoma is 28.6%. StageⅠ_a～stageⅡ_a is 76%, and stageⅡ_b and more are 24%; 15 patients has been pregnancy in 14 patients remaining reproductive function (during ovarian malignant tumor, stageⅠis 13 cases, stageⅡis 1 case), and the incidence of gestation is 67%. Univariate analysis showed that the different surgical methods of cervical cancer (whether to retain ovarian) has nothing to do with the survival rate (p=0. 83). Whether to retain reproductive function does not affect survival rate (p-0. 37). The stage of ovarian malignant tumor has something to do with prognosis (p-<0. 001). Stage remained to be independent prognostic factor in Cox proportional hazards analyses.Conclusions: 1. ovarian cancer is first in gynecologic malignancies of young women aged 10-30 year old, followed by cervical cancer and endometrial cancer; 2. The patients can be retained reproductive function on malignant ovarian germ cell malignant tumor, regaidless of how the stage. If the patients with EOC can be retained reproductive function, it is carefully limited to a strong demand reproduction, tumor stageⅠ_a, highdifferentiation and postoperative follow-up with closed conditions; 3. Diagnosis of cervical cancer in young women should pay attention to clinical characteristics, in particular the contact-type bleeding, attention to screen and gynaecological examinations; 4. Various conservative treatment of retaining ovarian function and reproductive function is of great significance; 5. Chemotherapy has no significant impact to ovarian function and fertility.