Clinical Analysis Of Ovarian Malignancy In41Young Female Patients

Objective:To investigate the clinical characteristics, treatment, the histological types, the,operational methods, the chemotherapy after the operation and the significance of retaining reproductive function and ovarian function in female patients with the ovarian malignancy tumors at the age of30or younger.Methods:To analyze retrospectively and summarize the clinical characteristics, treatment, pathology nature of tumor,staging,operational methods, chemotherapy after the operation、paragnosis and other clinical data in women at the age of30or younger, which are from Shandong Provincial Hospital of Shandong University in2001——2011. The data was evaluated by SPSS16.0analysis software. The difference was statistical significance when P<0.05.Results:During the last10years, there are41cases of patients with ovarian malignant tumors that aged30years old or younger in Shandong Provincial Hospital of Shandong University.The minimum age is13years old and the maximum age is30years old.The average age is21.6years old, and the median age is21years old. There are11cases of epithelial ovarian cancer,5cases of borderline ovarian tumors and17cases of ovarian germ cell tumors. It lacks of specificity clinical manifestations. Main shows are abdominal distension, abdominal pain and abdominal mass. A few patients have the menstrual symptoms related performance. Most of the clinical stage is earlier: Stage I in23cases,56.09%; Stage Ⅱ in3,7.32%; Stage Ⅲ 10patients,24.39%; Stage IV in5cases,12.19%.27patients keep reproductive function, including17cases of germ cell tumors,12cases of epithelial neoplasm,5cases of borderline ovarian tumors and3cases of sexual cable interstitial tumors. When follow-up period is over,27patients have fertility-sparing surgery (FSS),16patients are married,12patients have a brith plan and4patients pregnancy5times (phase I in3cases, and phase Ⅲ in2),the pregnancy rate is41.6%. With Kaplan-Meier survival function analysis, the clinical stages are the related factors affecting the prognosis.ConcIusions:For the young women who are30years old or younger,the germ cell tumor is captal and the clinical stage are earlier. Clinical manifestations are nonspecific, lack of early screening method; So we should attach importance and strengthen the gynecology imaging examination to the young women and adolescences. For young female patients’s ovarian germ-cell malignant tumors,no matter what clinical stage it is, all can keep reproductive function. For the epithelial malignant tumor IA-IC stage, the G1-G2period, the patients who have fertility requirements can be kept reproductive function, but must be long-term closely follow-up, This studying phase Ⅰ and phase Ⅲ which can keep reproductive function are successful cases of pregnancy, but they’re lack of a large sample of clinical proof. Management of young women diagnosed with gynecologic cancer should be individualized, with the risk of conservative therapy balanced against the disadvantages of more radical treatment.