Lumbar Interbody Spinal Fusion With Different Materials

Objective: Spinal fusion is one of the most common operation in spinal surgeon. Currently,autogenous iliac crest bone graft(OCBG)is the material of choice for spinal fusion.however, because of the complication and limitations associated with its use,like infection,pein and so on.Several strategies have been explored to enhance its function,or replace it altogether. The autograft substitutes were used in experiment and clinic.This study was performed to evaluate the capacity of the different materials in interbody spinal fusion in New Zealand white rabbit.The purpose is to provide the basis of the new substitutes application in clinic.Methods: The animals were randomly assigned five experimental groups: Group A was normal group. Group B was autogenous iliac bone graft group; Group C was allogeneic bone graft group; Group D was autogenous iliac-bioceramics composites group and Group E was rhBMP-2 composites group. All grafts were stuffed in vivo for spinal fusion. Gross inspection, manual palpation, radiography, biomechanical testing and histology were used to assess the spine fusion after the operation 4 weeks, 8 weeks, 12 weeks. Results: None of the animals were solid spinal fusion for 12 weeks in normal group; only 83.3% spinal fusion rate was achieved in autogenous iliac bone graft group; allogeneic bone graft group and autogenous iliac-bioceramics composites group were showed 66.7% solid spinal fusion; 100% spinal fusion rate was achieved in rhBMP-2 composites group. Conclusion: Allogeneic bone, autogenous iliac -bioceramics composites and rhBMP-2 composites could be used for interbody spinal fusion as an alternative of autogenous iliac bone graft for clinic treatment; the spinal fusion could be further accelerated mechanically with BMP-2.