Study On Relationship Between Ox-LDL And TCM Syndrome Of Unstable Angina Pectoris And The Effect Of Chinese Drug

Objective: Explore the relationship between Oxidized low density lipoprotein (ox-LDL) and TCM syndrome differentiation-type (TCM-SDT) of Unstable angina pectoris(UAP). And observe the intervention of HUATANFANG in ox-LDL of patients with UAP.Methods: 1. 96 patients with UAP were differentiated according to the standard of TCM syndrome differentiation-type for Coronary Heart Disease (CHD) revised in 1991 and the standard of Blood Stasis Syndrome revised in 1993. Among them 16 patients with Qi stagnation-Blood stasis Syndrome, 43 with Phlegm Turbid-Blood stasis Syndrome, 17 with Qi Deficiency-Blood stasis Syndrome,20 with Yin Deficiency-Blood stasis Syndrome. Otherwise 25 cases were selected to normal group. 2.All the patients with UAP were ranked according to the clinical risk level. 3. 43 patients with Phlegm Turbid-Blood stasis Syndrome were randomly divided into therapy group and control group. Both groups were treated by aspirin, statins, nitrate andβreceptor blocker and therapy group added HUATANFANG. Ox-LDL, Total Cholesterol(TC), Triglyceride(TG), low density lipoprotein Cholesterol(LDL-C), high density lipoprotein Cholesterol(HDL-C) and Fibrinogen(FIB) were determined before and after therapy. The clinical effect of both groups were compared after therapy.Results: 1 .The change of plasma ox-LDL and the relationship between ox-LDL and TCM-SDT of UAP.(1) The ox-LDL concentration of UAP group was obviously higher than that of normal group(P<0.01). According to clinical risk level, whether in low-risk group and medium-risk group, or in high-risk group, the plasma ox-LDL level was obviously higher than that of in normal group(all P<0.01). The ox-LDL level in medium-risk group and high-risk group was significantly higher than that of in low-risk group(all P<0.01). High-risk group was also significantly higher than medium -risk group(P<0.01).(2) There were some significant results about ox-LDL in TCM-SDT of UAP. Whether Qi stagnation-Blood stasis Syndrome, Phlegm Turbid-Blood stasis Syndrome or Qi Deficiency-Blood stasis Syndrome, Yin Deficiency-Blood stasis Syndrome, their ox-LDL levels were obviously higher than that of normal group(all P<0.01). The ox-LDL level of Phlegm Turbid-Blood stasis Syndrome group was significantly higher than Qi stagnation-Blood stasis Syndrome group(all P<0.01), and Yin Deficiency-Blood stasis Syndrome group was also significantly higher than Qi stagnation-Blood stasis Syndrome group and Qi Deficiency-Blood stasis Syndrome group(all P<0.01). There was no obvious difference between Qi stagnation-Blood stasis Syndrome group and Qi Deficiency-Blood stasis Syndrome group. There was also no obvious difference between Phlegm Turbid-Blood stasis Syndrome group and Yin Deficiency-Blood stasis Syndrome group.(3) There were some relation between TCM-SDT of UAP and clinical risk level. In low-risk group, the ratio of Qi stagnation-Blood stasis Syndrome group and Qi Deficiency-Blood stasis Syndrome group was obviously higher than with Phlegm Turbid-Blood stasis Syndrome, groups(all P<0.05). Both in medium-risk and high-risk group, the ratio of Phlegm Turbid -Blood stasis Syndrome group was obviously higher than other groups except Yin Deficiency-Blood stasis Syndrome group(all P<0.05).2. The effect of HUATANFANG to UAP(1) In UAP Phlegm Syndrome group, the plasma levels of ox-LDL, TC, TG, LDL-C and FIB were significantly higher than that of in normal group(all P<0.01).(2) After treatment, the ox-LDL levels were obviously reduced in control group and therapy group(all P<0.01). Compared with control group, in therapy group, the ox-LDL level was reduced markedly( P<0.05).(3) After treatment, the plasma levels of TC, TG, LDL-C and FIB were significantly reduced except HDL-C in control group and therapy group(all P<0.05). Compared with control group, in therapy group, the levels of TG and FIB were reduced markedly(P<0.05), and there was no obvious difference among the levels of TC, LDL-C and HDL-C.(4) The clinical effect of therapy group was significantly superior to that of control group (P<0.05).Conclusion: 1 .The plasma ox-LDL level of patients with UAP was abnormally high. The ox-LDL level could reflect the stability of coronary artery plague in a certain extent, having reference value in estimating the severity of patient's condition, and is valuable in predicting prognosis. 2. There were obvious differences among the levels of ox-LDL of UAP in different TCM type of syndrome and clinical risk level, therefore it was valuable in clinical practice that ox-LDL was regarded as objective marker of TCM-SDT and clinical risk level. 3. Plasma levels of ox-LDL, FIB and blood fat were abnormally high in the patients with UAP Phlegm Syndrome. Compound HUATANFANG with Western medicine can significantly reduce plasma level of ox-LDL, TC, TG, LDL-C and FIB, ameliorate clinical symptom, which was superior to using only Western medicine in some degrees.