Correlation Study On The Degree Of Coronary Artery Lesions With AIP And TCM Syndrome Types In Patients With Unstable Angina Pectoris

Objective: To analyze the correlation between the severity of coronary artery disease(Gensini score)and plasma arteriosclerosis index(AIP)and TCM Syndrome Types in patients with unstable angina pectoris(UAP),and to analyze the relationship between the relevant indicators and Gensini score,and to explore the distribution of TCM syndrome types,so as to provide the basis for clinical treatment and objectivity of TCM syndrome differentiation.Material and methods:From January 2019 to December 2019,107 patients with UAP of unstable angina pectoris of coronary heart disease who were hospitalized in the Affiliated Hospital of Liaoning University of traditional Chinese medicine(First Department of Cardiology)and Liaoning Provincial People's hospital were selected.The general data and blood lipid test results of all patients were collected,and the AIP value was calculated.According to the Gensini score standard,the patients were divided into three groups: Gensini score ? 60(severe lesion group),30 ? Gensini score < 60(moderate lesion group)and Gensini score < 30(mild lesion group).The patients were treated with TCM syndrome differentiation by two senior doctors,and the syndrome differentiation was recorded.Gender,age,smoking and drinking were analyzed.Rank sum test was used to analyze the correlation between TCM Syndrome Types and Gensini score,test of variance was used to compare the differences between UAP score subgroups and AIP value,and Spearman correlation was used to analyze the correlation between Gensini score and AIP.Results:1.AIP increased with the increase of Gensini score,and the difference was statistically significant(P < 0.01).At the same time,Gensini score of each lesion group was positively correlated with AIP.2.There was a certain correlation between different TCM syndrome types of UAP and the number of coronary artery lesions(P < 0.01).The proportion of heart blood stasis syndrome and phlegm turbid obstruction syndrome in the multi vessel group was significantly higher than that in the single vessel group,while there was no significant difference in the proportion of cold coagulation heart pulse syndrome,Qi Yin deficiency syndrome and qi stagnation cardiothoracic syndrome between the two groups3.The Gensini scores of different TCM Syndromes of UAP were statistically significant(P <0.01).The Gensini scores of heart blood stasis syndrome and phlegm turbid obstruction syndrome were significantly higher than those of cold coagulation heart pulse syndrome.The pathological process of Qi Yin deficiency syndrome,qi stagnation heart chest syndrome.4.There was no significant difference in TC and TG among Gensini score subgroups(P >0.05);With the increase of Gensini score,LDL-C increased gradually,and the differences among the three groups were statistically significant(P < 0.01);With the increase of Gensini score,HDL-C decreased gradually,and the differences among the three groups were statistically significant(P < 0.01).5.The distribution rule of TCM syndrome differentiation of UAP of coronary heart disease is as follows: 41 cases(38.3%)of phlegm turbid obstruction syndrome;20 cases(18.6%)of heart blood stasis syndrome;19 cases(17.7%)of cold congealing heart pulse syndrome;17cases(15.8%)of Qi Yin deficiency syndrome;10 cases(9.3%)of qi stagnation cardiothoracic syndrome.Among them,phlegm turbid obstruction syndrome accounted for the highest proportion.Conclusion:1.The higher the AIP value,the higher the Gensini score.AIP can be used as one of the clinical indicators to predict the severity of coronary artery disease,and it is more advantageous than single index.2.the TCM syndrome type of coronary heart disease is related to the degree of coronary disease.The genini score of the syndrome of stagnation of heart blood stasis and phlegm turbid Bi obstruction is significantly higher than that of cold coagulation heart pulse syndrome,Qi Yin deficiency syndrome and qi stagnation heart chest syndrome,heart blood stasis syndrome and phlegm turbid obstruction syndrome,which can provide objective basis for the differentiation of UAP syndrome.