Effect Of α-lipoic Acid(α-LA) On The Prevention And Treatment Of Nonalcoholic Fatty Liver In Rats

Effect ofα-lipoic acid(α-LA)on the Prevention and Treatment of Nonalcoholic Fatty Liver in RatsObjective To investigate the effects and mechanism ofα-lipoic acid(α-LA) on rat model of nonalcoholic hepatosteatosis.Methods ninety male Wistar rats were randomly divided into a normal(n=15)and an experimental group(n=75).The normal group rats were fed a standard diet,and those of the experimental group with a high-fat diet.After 8 weeks,the experimental group was randomly subdivided into three groups:one withα-LA treatment(n=45),one with vitE treatment and one without(n=15).4 weeks later,all rat were killed.Aminotransferase,free fatty acids(FFA),malondialdehyde(MDA),glucose(GLU),superoxide dismutase(SOD)were measured by biochemical methods.Result Compared with the model group, SOD ofα-LA group were significantly increased.The liver index,FFA,MDA,GLU and the level of serum aminotransferase ofα-LA group were significantly decreased.Conclusionα-LA can attenuate hepatic fat degeneration and inflammation of rats with fatty liver induced by high-fat diet through resisting oxidative stress and liperoxidation.It may become a new choice for fatty liver treatment in the future.