| The abnormality and damage of human body organ caused by each kind of factor common use the method of histological transplantation and substitutable item implantation to carry on the construction and repair.Developing ideal kind of substitutable material is research key in medicine domain at all times.This topic selects the silicone rubber(SR),the hydroxyapatite(HA) andβ-tricalcium phosphate (β-TCP) to compound under the guiding ideology of sole material compound hybridization can optimized performance,and also based on the silicone rubber(SR) and the calcium-phosphorus bioceramics having their advantage and disadvantage respective.The topic also examine biomechanics performance according to the People's Republic of China country standard,comparing with present clinical practice SR.The meaning that we study the Calcium-Phosphate Ceramic/Silicone Rubber is to use the biological inertia and good shape of SR for filling in the human body as filled bracket and prosthesis in the surgical operation;The research use the degradation property and organization substitute of calcium-phosphorus as the substance for changing bracket's surface character,which substituting surrounding organization for bioceramics,enabling the silica rubber to have better biological compatibility,making new kind of organization filler.This compound material has following property:1,Excellent plasticity.The silicone rubber and the calcium-phosphate bioceramics are both the clinical commonly solid material.The plasticity of mainly compound by silica rubber is equal to the pure silica rubber.2,Excellent biomechanics performance.This compound material is the silica rubber with few calcium-phosphorus bioceramics grain,which best compound proportions are main research questions in this test.3,Excellent biological compatibility.The organization gradually forms bone ingredient after it entering.The organization combine with SR ingredient of non-degradation property.Methods:1,To quantified analyze the particle size of HA,β-TCP,screens out the best grain scope of HA,β-TCP material for clinical need.2,To prepare different proportion of HA/SR,β-TCP/SR in the sulfuration stage of silica rubber according to the mixes law.3,To scan and observe the compound material using electron microscope.4,To appraise the pull strength intensity,pull strength ratio,the permanent deformation rate(3 min),the rigidity and biomechanics performance according to the national standard.Result:1,To prepared HA,β-TCP quality allocated proportion 30(in 100gSR has joined biological ceramics quality is 30g,below with),50,70 compound materials.Through the observation,HA grain average granularity is 52.28μm,andβ-TCP grain average granularity is 76.15μm.2,Through researching the HA,β-TCP grain by preliminary granularity determination and compound electricity microscope find few grain disruption phenomenon in the process of mixing with SR,but the majority grain are full and integrity.3,With the increase of biological ceramics content in silica rubber,the compound materials are not obvious difference compared with pure SR,when the quality allocated proportion of HA,β-TCP is 30;when which is 70,the rigidity of compound material enhance gradually,while the biomechanics performance drops obviously.Conclusion:1,This experimental HA/SR,β-TCP/SR compound material has the excellent biological-mechanics performance of silica rubber,which can overcome shortcoming of sole material using in clinical,also can satisfy the biological compatibility and chemistry good nature simultaneously.2,The calcium-phosphorus bioceramics ingredient can not be increased unlimitedly among the 3 kind of proportions HA/SR,β-TCP/SR compound.With the increase of calcium-phosphorus bioceramics ingredient,each biological-mechanics performance index assumes the drop tendency.3,The shape and replacement of calcium-phosphorus bioceramics in human body has always puzzled clinician.The compound material is compact and mixed by organic and inorganic,which enable the material to have elasticity,and is easier to carve the shape comparing with the purer massive calcium-phosphorus bioceramics;The compound material is easy to disinfect;of low raw material price,mature preparation craft,low cost,and broad application prospect. |
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