Study On The Potassium Titanate And Nano-Hydroxyapatite For Artificial Bone Applications

At present, the common bioceramic materials used in artificial bone are HA,β-TPC, and so on. Potassium titanate sinters used for artificial bone were prepared based on present application of potassium titanate in biomedicine fields. The microstructure and phase composition of potassium titanate sinters were analysed using SEM and XRD. The surface energy of potassium titanate was tested by capillarity osmosis process. The nano -hydroxyapatite which was cultured in simulated body fluid, together with potassium titanate used for experiment of cell cultivation. The research results are indicated as follows:1. The whiskers were clustered outside sinters surface, but they were crisscrossed pattern in the sinters. They were pore-rich structure and the worse compactness. The results indicated that when the molar ratio of K₂CO₃ and TiO₂ was 1:4, it is mainly made of K₂Ti₄O₉ in sinter, when the molar ratio of K₂CO₃ and TiO₂ was 1:6, it was mainly made of K₂Ti₆O₁₃ in sinter. The shape of potassium titanate whiskers were impacted on the holding time. Compared with K₂Ti₄O₉, the size and the aspect ratio of K₂Ti₆O₁₃ were small, and the surface energy of K₂Ti₆O₁₃ was large.2. The capacity of inducing deposition of Ca-P on the surface of different potassium titanate sinters in inorganic SBF was better. There were morphological differences between deposition in inorganic SBF and organic SBF. The organic element of azote was existed in this powder, so the nano-HA conformed as human bone in organic SBF. Biomineralization and biological self-assembly theory used of discuss the nucleation mechanism. 3. The calcium phosphate hydrate was cultured in inorganic or organic simulated body fluid. The powder was investigated using SEM, EDS, TEM, XRD and FTIR. It was indicated that the apatite was needle-like and low degree of crystallinity. The organic element of azote was existed in this powder, so the nano-HA conformed as human bone in organic SBF.4. To evaluate the biocompatibility of materials in vitro, osteoblast cells(OCT-1) were cultivated with substitutes for bone tissue, including K₂Ti₄O₉, K₂Ti₆O₁₃ and HA. The results indicated that both materials had no obvious effect on the proliferation of the cells. Both materials were biocompatible to osteoblast cells. Both materials could promote the migration and attachment shape and proliferation rate of cells were good. While potassium titanate was a better substitute for bone tissues, for it has better osteogenic action.