Retrospective Investigation Of Invasive Pulmonary Fungal Infection In Second Hospital Of Jilin University During Last 10 Years

Background: With the economy in recent years and increasing the level of medical care, due to the long-term application of broad-spectrum antibiotics, all kinds of intrusion detection equipment, the in vivo catheter intervention, high-intensity immunosuppressive medicament and high-dose chemotherapy and the extensive application of rising technologies such as hematopoietic stem cell transplantation, substantiality organ (liver, kidney, heart and other organ) transplantation in clinical, the incidence of invasive pulmonary fungal infection (invasive pulmonary fungal infections, IPFI) had became a marked increase in evidence. Also became to be one of causes to death increasingly , especially to organ transplant recipients, patients with hematologic malignancies and malignant tumors, as well as other critically ill patients.Objective: To accumulate epidemiological and clinical data of domestic invasive pulmonary fungal infection in recent years, explore the clinical characteristics and treatment of IPFI to increase the knowledge about IPFI for clinicians, which help to make early diagnosis and treatment and provide a theoretical basis, as well as perfecting the invasive pulmonary fungal infection in the diagnostic criteria and treatment principles,.We have analyzed the case about invasive pulmonary fungal infection from the second Affiliated Hospital of Jilin University.Methods: Analysis the information of patients diagnosed as invasive pulmonary fungal infection in Second Affiliated Hospital of Jilin University, to explore invasive pulmonary fungal infection risk factors. Retrospective analysis from Jan 1998 to on in Dec 2007 in the Second Affiliated Hospital of Jilin University, we get 19 cases of fungal infections confirmed by the microbiology or pathology tests, discuss the correlations between inefctions and age of all cases, the basic disease, the risk of factor, treatment,.Results: 1, IPFI fungal origin:12cases of Candida,4 cases of aspergillosis, cryptococcosis 1 cases, 2 cases of infection caused by unknown fungal. Candida albicans is the most common in Candida, accounting for 66.67% of Candida, accounting for 42.11% of all cases of IPFI, the rest's Candida krusei and Candida glabrata, accounting for 16.67% Candida. In addition to Candida, the most common Aspergillus in total cases (21.05%). 2, The combined basis disease respiratory diseases in IPFI was most common, above to a total of 10 cases (52.62%), in which chronic obstructive pulmonary disease (COPD) 5 cases (26.32%), diffuse interstitial lung disease (ILD) 1 cases ( 5.26%), 2 cases lung cancer (10.53%), 2 cases bronchial asthma (10.53%), bronchiectasis in 1 case (5.26%), tuberculosis in 1 case (5.26%), There are 4 cases of diseases about the circulatory system (21.05% ), 2 cases of systemic diseases (10.53%), 3 cases of cerebrovascular disease (15.79%), 3 cases of diabetes (15.79%), 2 cases of malignant tumors (10.53%). 7 patients (36.84%) have combined for more than two kinds of diseases. 3, Antibiotic treatment before fungal infections : ll patients diagnosed IPFI have been used antibiotics in last 30 days, 14 patients have combined applicated antibiotics more than 14 days before diagnosed, including penicillin used in 8 cases (42.11%), third and fourth generation cephalosporins in 9 cases (47.37%), 5 cases of macrolide antibiotics (26.32%).4,other: 14 patients were the elderly(≥65),11 patients with HypoproteinemiaConclusion: Candida is found in invasive pulmonary fungal infection fungi, particularly the most common Candida albicans, Aspergillus but also occupy a certain proportion. Through the analysis of fungal infection-related factors that occurred mainly in IPFI respiratory diseases, especially COPD, lung diseases such as malignant tumors, while long-term use of a variety of broad-spectrum antibiotics, hypoproteinemia, is caused by the use of hormones and other risk factors IPFI , similar to other studies at home and abroad.1, It's hard to diagnostics IPFI due to badly state of patient, lag of diagnostic techniques about fungal, ossification of clinical viewpoint.2, Candida is the most common epiphyte in our hospital invasive pulmonary fungal infection, particularly the most common Candida albicans, Aspergillus also occupy a certain proportion.3, Respiratory diseases are most common combine disease in IPFI patients, especially COPD as well as malignant tumors.4, We can find some common risk factors of IPFI such as the elderly, long-term using a variety of broad-spectrum antibiotics, hypoproteinemia, similar to other studies at home and abroad.