Curative Effects Observation Of Continuous Subcutaneous Insulin Infusion And Multisubcutaneous Insulin Injection In Newly Diagnosed Type 2 Diabetic Patients

Objective:The paper intends to explore the effect of short-term intensive insulin treatment on pancreaticβ-cell function and glycemia control in newly diagnosed type 2 diabetic patients with severe hyperglycemia.Methods:The subjects are seventy-nine hospitalized newly diagnosed type 2 diabetic patients aged 50±11,and among them 45 are males and 34 are females.According to the patients' wills,they were divided into 2 groups to undergo intensive insulin treatment with continuous subcutaneous insulin infusion(CSII group,n=40) or multisubcutaneous insulin injection(MSII group, n=39) for 2 weeks.The targets of glycemia control included fasting blood glucose(FBG)＜6.0mmol/L and 2h postprandial blood glucose(PBG)＜8.0 mmol/L.The changes of blood glucose and the time and the doses of insulin needed for good glycemic control were compared between the two groups.The frequency of hypoglycemia and pump-related side effects were recorded.Results:On the 2^nd day of intensive insulin treatment FBG and 3 meals PBG levels were significantly reduced in both groups while the post-breakfast and post-dinner blood glucose levels were far more decreased in the CSII group than in MSII group(8.6mmol/L±2.7mmol/L vs 11.5mmol/L±3.Tmmol/L and 9.2mmol/L±2.3mmol/L vs 10.9mmol/L±2.7mmol/L both p＜0.05).The FBG and 3 meals PBG were significantly lowered in the CSII group than in the MSII group on the 7^th day and after the stopping of intensive insulin treatment.The time of good glycemia control of the CSII group was 48h,which was significantly shorter than that of the MSII group(144h p＜0.01).The mean dose of insulin used during insulin pump therapy in CSII group was 0.6u/kg,which was significantly less than the MSII group(0.8u/kg p=0.002).There was no significant difference in mean area under the curve(AUC) of insulin and C peptide during OGTT,Homa-βand Homa-IR between the two groups before and after intensive insulin treatment.No pump-related side effects were observed in both groups.Conclusion:The excellent glycemia control and improvement ofβ-cell function can be induced by short-term intensive insulin treatment in newly diagnosed type 2 diabetic patients with severe hyperglycemia.CSII was more effective and faster with less doses of insulin in acquiring good glucose control compared with MSII.