Comparing The Difference Of Bone Mineral Density Reference Databases For Multiple Skeletal Regions In Women Between In Qingdao And Changsha Area In China

Objective Establishing the bone mineral density(BMD) reference databases of multiple skeletal regions in women in Qingdao and then to compare the differences of the BMD databases from Qingdao and Changsha area in China by calculating the fomulus of the varied type dual-energy X-ray absorptiometries(DXAs).The aim is to find the way which could share the different databases from the varied type DXAs.Method BMD was measured by Challenger(DXA,DMS Co.France) at skeletal regions of supine normotopia spine,left hip(femoral neck,greater trochanter and ward's triangle) in 868 healthy women aged 25-83years in Qingdao.BMD of skeletal regions with age-related changes were found to fit in whole of eight kinds of regression models.Best model equations of fitting was found and the reference databases were established,then to be compared with that in Changsha area where BMD was measured by Hologic QDR 4500(DXA,America).Meanwhile,30 healthy women aged 25-35 were selected and had their BMD measured by the different DXAs(Challenge and Hologic) at skeletal regions above mentioned.Then we found the emendation formulus from the two varied DXAs by linear correlation and regression analysis,and compared the different BMD databases from Qingdao and Changsha areas respectly.Results 1.BMD reference databases changed with aging and the peak BMD of lumbar spine and hip in Qingdao appeared at 25-29 and 40-44years old groups respectively,while Changsha at 30-34years old groups.2.The BMD reference databases were established by cubic regression equation,which was better fitted with age-related change as compared with other regression models.The coefficients of determination(R~2) of fitting curve were 0.21±0.09(P＜0.001).3.BMD measured by Challenger and Hologic QDR 4500 were predominantely correlated,and there exists linear relationship.4.There is significant difference of BMD between both areas,especially in the hip regions Qingdao women are higher than Changsha area before data emendation.In fact the BMD databases of the both areas showed no significant difference after emendation.Conclusion 1.It is necessary to establish the local reference database of BMD for the PBMD age were different in different areas.2.The effectors of measuring BMD include region,diary habits,sex, BMI,especially the types of the measuring equipments.Postgraduate student:Qiu-LingWang(endocrinology and metabolism) Directed by Prof.Nai-LongYang...