Relationship Between Serum Matrix Metalloprotease-9 And Tissue Inhibitor Of Metalloproteinase-1 And Bone Mineral Density In Postmenopausal Women

Objective: To study the relationship between matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1) and bone mineral density(BMD) in postmenopausal women. By comparing the serum MMP-9 and TIMP-1 in different BMD conditions of postmenopausal women, to find out the function and variation of both in osteoporosis(OP) and to provide the data in the clinical diagnosis and treatment of OP.Methods: Dual energy x-ray absorptiometry (DXA) was used to measure BMD of six skeletal regions of lumbar spine (L2-L4) and the left hip department (femoral neck, Ward's triangle and greater trochanter). 80 postmenopausal women were divided into normal BMD group(n=21), low BMD group(n=20), osteoporosis group(n=23) and serious osteoporosis group(osteoporosis bone fracture group, n=16). Each group was carried out the routine inspection such as height and weight, and measured serum MMP-9 and TIMP-1 by ELISA.Results: (1) With the decreasing of BMD, the serum level of MMP-9 in postmenopausal women had an increased tendency. It was notable in osteoporosis bone fracture group. It was approved deeply the association of MMP-9 level and OP. (2) There was no statistical significance in serum density of TIMP-1 between low bone quantity group, osteoporosis group and normal comparing group. It couldn't indicate that TIMP-1 play an important role in OP. (3) The ratio of serum MMP-9 and TIMP-1 in postmenopausal women was higher in three groups in turn,from the normal group to osteoporosis group. The ratio imbalance between MMP-9 and TIMP-1 may be an important factor for OP.Conclusion: The high level of MMP-9 and the ratio imbalance with the TIMP-1 could be an important factor for postmenopausal osteoporosis .