Using Sap, The Dxa And Biomechanical Determination To Observe The Effect Of Compound Chinese Herb On Ovariectomized Rat Osteoporosis Model

Objective:To study the effects of NF(new fomula) on the bone mineral dencity (BMD),ultimate load (UL), ultimate deformation (UD) of ovariectomized rats.Methods fifty-nine 3-month-old femal SD rats were randomly divided into six groups:false operation group(all were operated without spay); ovariectomized Group (OVX);estrin group;NF(new formula)groups (epimedium,astyagalusroot,gloss privet fruit,etc) with low dosage(NF+L) ;NF groups with moderate dosage(NF+M); NF groups with high dosage(NF+H);The experiment last for three months .At the end of it ,the BMD and BMC of left femoral distial metaphysis of all groups was determined with SAP;The BMD of left femur was measured with DXA. Ultimate load (UL) and ultimate deformation (UD) of right femur of all groups were measured with electronic universal experimentai apparatus..Results; The BMC and BMD of rats' left distal femur of OVX group which were measurd with SAP was significantly lower than that of false operation group (p<0.01), the BMC and BMD of other groups were significantly higherer than that of OVX group (p<0.01).Tthe BMD of rats' left femur of OVX group which were measurd with DXA was significantly lower than that of false operation group (p<0.05); BMD of NL+L group showed an increasing trend compared with OVX group.BMD of other groups had no significane of difference as compared with OVX group .The UD and UL of NF+M group was significantly highter than that of OVX group(p<0.01). NF+M played a role in improve biomechanics nature of bone with osteoporsis.Conclution :New formula improve the BMD and BMC of the OVX rats. NF+M may improve the bone biochemical properties of OVX-rats;The bearing capacity of bone tissue was increased;The resistance of skeleton against external force was improved. The results suggsested that the :new formula capsule improve the bone loss of ovariectomized rats and prevent osteoporosis.