Clinical Studies On Plasma Anticardiolipin Antibody In The Patients With Ischemic Cerebrovascular Disease

Background and Purpose The incidence rate,the recurrence rate,the lethality and crippling rate of the cerebrovascular disease is high,it with heart disease,the malignant tumor constitutes humanity's three approx- imately dead causes of disease.At present did not have the ideal method to treat the ischemic cerebrovascular disease,therefore seeks its related hazard factor and carries on positively intervenes to cuts the disease incidence rate,the instruction to treat and improves the patient prognosis to have the very vital significance.Anti-cardiolipin antibody(aCL) is one kind the belt negative charge cuorin takes the target antigen by in the blood platelet and the bast cell membrane own immune body,it is common in systemic lupus erythematosus(SLE) and other own immunity vigorous sickness,aCL is until now knows the direct suggestion blood to congeal high the condition only own immune body,aCL may cause the thrombus in vivo to form was confirmed repeatedly by the mouse animal experimentation institute.Unceasingly was in recent years thorough along with the research and the diagnosis technology changes with each new day,the literature report confirmed that in the blood plasma aCl and the ischemic cerebrovascular disease relations were close.But not sees on the anticardiolipin antibody positive ischemic cerebrovascular disease patient's clinical characteristic's research,this research has carried on the discussion to this question,provides the basis take the time as the ischemic blood vessel of brain's prevention.Methods This research chooses in January,2008-2009 year in January in the first hospital of Jilin University neurology department in hospital ischemic cerebrovascular disease patient(152 examples),the patient is hospitalized in the latter 24 hours,uses the ELASI testing method to determine in the patient blood plasma anticardiolipin antibody IgAGM.Divides into according to the determination result the patient aCl(+) group(56 examples) and the aCl(-) group(96 examples),compared with two group of patient formerly medical histories, individual history,laboratory and phantom study inspection material,recrudescence situation and so on.Results 1.In the sex aCl(+) group of females are more than aCl(-) the group,two group of comparison differences have statistics significance(X~2=4.70,p＜0.05),In morbidity age two group of not obvious statistics differences(t=1.961,p＞0.05).2.aCl(+) group compares diabetes, hypertension,coronary disease,the hyperlipemia with the aCl(-) group,to smoke and to drink wine the history not obvious statistics difference(p＞0.05).3.aCl(+) group with aCl(-) when group patient in hospital the systolic pressure,the diastolic pressure level,the total cholesterol,the low density lipoprotein cholesterol,the glycerin,the fibrinogen and the blood sugar level carry on the comparison,two group of not obvious statistics differences(p＞0.05).4.aCl(+) group of MRI inspections have frequently-occurring disease stove's patient population to be more than the aCl(-) group obviously,two group of comparison differences have statistics significance(X~2=10.70,p＜0.05). 5.Two group of DSA or MRA demonstration arteriostenosis situation(X~2=1.07),carotid artery supersonic inspection(X~2=1.03),TCD inspection(X~2=3.05),microemboli signal test result (X~2=0.53),compared with result not obvious statistics difference(p＞0.05).6.aCl(+) group has the anemic apoplexy recrudescence history patient population to be higher than the aCl(-) group obviously,two group of comparison differences have statistics significance(X~2=5.28, p＜0.05)。Conclusion 1.aCl(+) ischemic cerebrovaseular disease patient is in the majority by the female,the MRI inspection has frequently-occurring disease stove's patient population to be more than the aCl(-) group,aCl(+) group of isehemic cerebrovascular disease patient is easy to recur.2.The age,the blood pressure,the blood fats level,the fibrinogen and the blood sugar level in two groups of not obvious differences,two group of patient partners send the trunk narrow and the unstable mottling situation do not have the difference.