Clinical Study On Predicting Value Of Hs-CRP、MCP-1、PIGF Combined With ABCD~2 Score In Patients’ Progression From Transient Ischemic Attack To Cerebral Infarction

Objective: To explore the value of hs-CRP、MCP-1、PIGF combined with ABCD2 score in predicting the risk of transient ischemic attack(TIA) evolving into cerebral infarction(CI) within 7 days.Methods:Ninety patients diagnosed TIA in NO. 285 Hospital of China People’s Liberation Army were collected from Jan 2014 to Jan 2015. Patients were included in the CI group(22 cases) if they progressed to CI within 7 days from onset, others were included in the non-CI group(68 cases). The common cerebrovascular disease risk factors, hs-CRP level, MCP-1 level, Pl GF level and ABCD2 score were recorded. Single factor analysis of was used for the differences of cerebrovascular disease risk factors, hs-CRP level and ABCD2 score between the CI group and the non-CI group. According to their level, hs-CRP≤3mg/L 、Pl GF≤20 pg/ml、MCP-1≤245pg/ml and hs-CRP>3mg/L、MCP-1>245pg/ml、Pl GF>20pg/ml, all patients were stratified. Then combined with the ABCD2 scores≤3 or >3, the two groups were respectively divided into two groups. Hs-CRP≤3mg/L、Pl GF≤20 pg/ml、MCP-1≤245pg/ml and ABCD2 scors≤3 group was the baseline group, other groups were respectively compared with the baseline group by Logistic regression analysis to evaluate the risk of ort-term progression to CI.Results: Baseline data of single factor analysis: the average age(65.20±8.6) years, hs-CRP level( 6.10±3.51) mg/L, MCP-1 level(456.60±83.35) pg/ml, Pl GF level(25.61±4.77)pg/ml and ABCD2 score( 4.68±1.24) were higher in the CI group than that in non-CI group[( 61.10±7.6) years,( 3.65±3.52) mg/L,(248.58±58.38) pg/ml,(20.70±4.83)pg/ml,(3.52±1.49)score respectively], each difference had statistical significances(P<0.05). Logistic regression analysis: with hs-CRP>3mg/L、MCP-1(pg/ml)>245pg/ml、Pl GF>20 pg/ml and ABCD2>3, the TIA patients’ short-term risk of progression to CI was 10.749 times higher than the baseline group(95% CI: 3.419-34.283, P<0.05), after controlling for the effects of age, gender, hypertension, diabetes mellitus, stroke history of family and smoking, the risk of progression in CI was 13.451 times higher than the baseline group(95% CI: 3.221-56.753, P<0.05).Conclusions:ABCD2 score was a simple and effective tool in predicting TIA patients’ short-term risk of progression to CI, and hs-CRP, MCP-1, Pl GF levels combined with ABCD2 score could improve the predictive value.