Expression Of PTTG And VEGF-C In Human Pancreatic Carcinoma: Significance And Relationships To Clinical Tumor Behavior

Objective:For a long time we are deeply impressed by the aggressive biological behavior and poor prognosis of pancreatic ductal carcinoma because there is no specific tumor marker for the early diagnosis and lack of effective therapy in time.It is necessary and urgent to find the specific tumor markers with diagnostic value and therapy target for improving the diagnosis and prognosis of pancreatic carcinoma. During the research on oncomolecularbiology of pituitary tumor we have found that PTTG as a promoter of cell multiplication.The following studies illustrated that PTTG and VEGF-C played an important role in many tumors.Considering that tumors from different origin are similar in biological behavior including both aggression and metastasis,PTTG and VEGF-C also play an significant role in the tumorigenesis, development and progression of pancreatic ductal carcinoma possibly.This objective is to investigate expression of PTTG and VEGF-C and their correlationship with clinicopathologic characteristics in pancreatic carcinoma.The correlationship between PTTG and VEGF-C is also involved in.Methord:PTTG and VEGF-C were detected by S-P immunohistochemical staining in 45 case of pancreatic carcinoma,using the same way in 15 case of pancreatic benign tumor and 8 case of pancreatic normal tissue as contrast.The experimental results were analyzed by using CHISS2004 statistical software to show correlation between PTTG and VEGF-C.Result:The positive rate of PTTG and VEGF-C protein in 45 cases of pancreatic ductual carcinoma tissue was 88.9%(40/45) and 69.9%(31/45) respectively.Expression of PTTG and VEGF-C in pancreatic carcinoma is higher than in normal pancreas tissue and pancreatic benign tumor(P<0.05).According to the degree of PTTG and VEGF-C expression,45 patients were divided into two groups:high expression group and low expression group.There was no statistically significant difference in age,gender,tumor size between the two groups(P>0.05).There were statistical differences in tumor differentiated degree and local metastasis according to the degree of PTTG expression, while the statistical differences was in lymphatic metastasis according to de expression of VEGF-C.Spearman's rank correlation analysis showed a positive correlation between expression of PTTG and VEGF-C protein(P<0.05).Conclusions:(1),The positive rate of PTTG and VEGF-C in pancreatic carcinoma was higher than that in normal pancreatic tissue which indicated that both were participated in the tumorigenesis,development and progression of pancreatic ductal carcinoma.(2),Significant correlation with differentiation of pancreatic carcinoma and lymph node metastasis suggested PTTG and VEGF-C may involve in the development of pancreatic carcinoma.(3),Positive correlation between expression of PTTG and VEGF-C implied they were cooperated in development and metabasis of pancreatic carcinoma.(4),PTTG and VEGF-C are potential markers of metabasis and prognosis in pancreatic carcinoma.