Overexpression Of PTTG, VEGF-C And MMP-14 In Breast Invasive Ductal Carcinoma And Their Clinicopathologic Significances

Objective: To investigate the expression of pituitary tumor transfor-ming gene (PTTG), matrix metalloproteinase-14 (MMP-14) and vascular endothelial growth factor-C (VEGF-C) in human breast invasive ductal carcinoma. Try to illuminate their correlations to clinicopathologic featur-es of breast invasive ductal carcinoma.Method: Immunohistochemistry method were used to detect the ex-pressions of PTTG, MMP-14 and VEGF-C in breast invasive ductal carci-noma. Breast slices of 40 cases definitely diagnosed as breast invasive ductal carcinoma and 20 benign cases were collected.Result: There were higher expression of PTTG, VEGF-C and MMP-14 in breast invasive ductal carcinoma than in benign lesions(P<0．05) . There were no significant differences between the expression of PTTG, VEGF-C, MMP-14 and age, size and differentiation of tumor(P>0．05) , b-ut there were statistical relationships between their expression and TNM stage and lymph node metastasis(P<0．05) . The expression of PTTG was positively correlated with VEGF-C and MMP-14 expression.Conclusion: Tumor lymph angiogenesis is enhanced by the overexp-ression of PTTG, VEGF-C and MMP-14．PTTG, VEGF-C and MMP-14 have some meaning in judge the biological behavior and the prognosis of breast invasive ductal carcinoma; PTTG, VEGF-C and MMP-14 may be used as new targets of anti-lymphatic therapy for breast invasive ductal carcinoma.