The Capsule Of Shuhe In The Treatment Of IGT In Clinical Research

Objective:This subject to be observed before and after treatment through physical improvements and fasting blood glucose,two-hour postprandial bl ood glucose(oral glucose after anhydrous 75G),fasting insulin,two-hour postprandial insulin(after oral glucose anhydrous 75G),insulin sensiti vity index,blood lipids,such as indicators and clinical point of view from impaired glucose tolerance(IGT) to diabetes evolution,in order to Qingre Huazhuo preliminary study for the treatment of traditional Chinese medicine Shuhe capsule' s formulations to improve the role of the possibl e mechanism of IGT,as well as the regulation of glucose metabolism and b lood lipids,obesity,blood pressure and other risk factors for changes i n the law between the understanding of Chinese medicine.Methods:A prospective randomized single-blind clinical study of the control method.Observation of 20 cases of out-patientcases,20 cases of hospitalized patients,a total of 40 cases,a simple test group were randomly assigned to 20 cases,20 cases of the control group and the establishment of strict diagnostic criteria,inclusion criteria,exclusion criteria.:Treatment group:taking capsule of Shuhe,4 capsules / time,2 times / day,for taking three courses,a course for 30 days.Control group:taking acarbose(acarbose), 50mg,3 times / day,taking meals in a row taking three courses,a course for 30 days.Designed to observe patients before and after the test form of physical records to improve the situation,laboratory indicators,the information the results of clinical input into the computer,the establishment of databases, data management,application software for simple statistical data analysis, statistical methods of information classification test using X²,multi-group are few compared with ANOVA(analysis of variance),and adverse events,a detailed record of adverse reactions.Results:The treatment group patients treated by capsule of Shuhe in March, the overall effect of Chinese medicine than in the control group improved significantly,with a total effective rate was 90%.Clinical symptoms in all patients with significant physical improvements,the clinical cure rate was 37.5%,46.4%effective rate was 83.9 percent overall efficiency;the control group patients were treated three months later,symptoms and signs of improvement in overall response rate was 55%:of which 30.4%clinical cure rate,effective rate was 41.9%,total effective rate was 72.3%,respectively. Inter-group comparison showed that the treatment group on the physical side impaired glucose tolerance in patients with the wet side of the mouth feel hot,the tone light and heavy,restaurants partial Anopheles,toilet cases, mental status,gastrointestinal,as well as the treatment of the tongue,such as the role of the pulse is better than the control group After statistical processing,were significantly different(P＜0.01).Treatment group and control group after treatment there was some improvement in blood glucose, compared with before treatment,the difference was significant(P＜0.05-0.01), but capsule of Shuhe' s P2HBG treatment in March after declining significantly over the control group(^ΔP＜0.05,^ΔΔP＜0.01);0.01);the treatment group and control group after treatment compared also significant differences,compared with the control group,capsule of Shuhe of P2HBG more significant improvement(*P＜0.05);the treatment group to improve the efficiency of glucose significantly higher(P=0.0386＜0.05).capsule of Shuhe that single-drug therapy on the physical side impaired glucose tolerance in patients with wet heat partial improvement in blood sugar have a good role. In glycosylated hemoglobin,body mass index,waist-hip ratiO,CRP,ESR,UA, the difference between the two groups is also significant(P＜0.05),efficacy of the treatment group than the control group.Oonclusion:Capsule of Shuhe in the treatment of impaired glucose tolerance have a better clinical efficacy,to refute the past,Chinese medicine in improving laboratory indicators in patients with deficiencies in the treatment of proven effectiveness of traditional Chinese medicine differentiation;In this study,a single treatment of Traditional Chinese Medicine IGT,and compared the effects of western medicine,western medicine is different from the previous joint-control study carried out to avoid the West also in therapy also may cause side-effects;Chinese medicine have hypoglycemic,lipid,weight, blood pressure and improve insulin resistance,such as the role of Western Although treatment can achieve good results,but also can cause metabolic disorders,and side effects,targeted single.Chinese targets,and tolerance, and unity to overcome the Western side effects caused.Therefore,the correct use of Chinese medicine treatment of impaired glucose tolerance dialectical there are a lot of prospects.