Expression Of Fascin And Kail/CD82 In Pancreatic Adenocarcinoma And Their Clinic Significance

Objectives To study the expression of Fascin and Kail/CD82 in pancreatic adenocarcinoma and their clinical significance.Methods The expression of Fascin and Kail/CD82 in 47 specimens of paraffin-embeded pancreatic adenocarcinoma and 25 normal pancreas around tumors was detected by using immunohistochemistry staining(PV9000) and compared with clinicopathological data.Results (1) The positive rate of Fascin expression in pancreatic adenocarcinoma was80.9 %(38/47), and that in normal pancreatic tissue was12.0%(3/25). There was statistical difference between them(P<0.01). (2) The positive rate of Kail/CD82 expression in pancreatic adenocarcinoma and in normal pancreatic tissue was 34.0%(16/47),84.0%(21/25),respectively. There was statistical difference between them(P<0.01). (3) There was no significant difference among the expression of Fascin in different sex,ages,tumor location and tumor diameter of the cancer, however there was a relationship with the differentiation of carcinoma , the metastasis of lymph nodes and the clinical stages. (4) There was also no significant difference among the expression of Kail/CD82 in different sex,ages,tumor location and tumor diameter, however there was a relationship with the differentiation of carcinoma, the metastasis of lymph nodes and the clinical stages. (5) The expression between Fascin and Kail/CD82 had a significantly negative relation in pancreatic adenocarcinoma (χ2=21.37, P<0.01). Relevance of them was measured by Pearson in numerical, C =0.559.Conclusions (1) Fascin was highly expressed in pancreatic cancer and the expression of Fascin was associated with the differentiation of carcinoma, the clinical stages and the metastasis of lymph nodes, the expression of Fascin was increased with the degrading differentiated degree, the heightening the clinical stages and the infiltrating lymph nodes, which indicated that it might be a useful tumor marker to assess the tumor's malignant behavior.(2) The expression level of Kail/CD82 in pancreatic carcinoma was signifcantly decreased compared with that in nearby tumor free tissues, and it was significantly correlated with the pathological grading, lymph node metastasis and the clinical stage, which indicated that Kail/CD82 was correlated with the tumor metastasis, proliferation, cancer progression and tumor cell adhesion of pancreatic carcinoma and it might be a useful tumor marker of pancreatic carcinoma.(3) The level of Fascin and Kail/CD82 may be a sensitive predictor of proliferation, differentiation, invasion and metastasis of pancreatic adenocarcinoma.