Expression And Clinical Significance Of Heparanase And Vascular Endothelial Growth Factor In Pancreatic Carcinoma

Objective:To explore the expression of heparanase(HPSE) and vascular endothelial growth factor(VEGF) in pancreatic carcinoma and their clinical significance. Methods:45 cases of pancreatic carcinoma,and 20 cases of adjacent normal pancreatic tisse,were chosen to explore expression of HPSE and VEGF by immunohistochemistry (SABC) method.Results:The positive expression rates of HPSE and VEGF in 45 cases of pancreatic carcinoma(73.3%,77.8%) were significantly higher than that in adjacent tissues of carcinoma(10%,15%),(χ~2 =22.35,22.47,p＜0.05),The negative expression of HPSE and VEGF were in normal pancreatic tissues.The positive expression rates of HPSE and VEGF in pancreatic carcinoma tissues with metastatic lymph node(83.3%,86.7%),and in advanced TNM stage(Ⅲ-Ⅳ)(81.2%,87.5%) were higher than that in those without metastasis(53.3%,46.7%)(χ~2=4.60,7.78,p＜0.05) and in early TNM stage(Ⅰ-Ⅱ) (46.2%,53.8%)(χ~2=6.91,6.06,p＜0.05).The positive expression of HPSE was corelated to the positive expression of VEGF in pancreatic carcinoma(r_s=0.520,p＜0.01).Conclusion:There are high expression of HPSE and VEGF in pancreatic carcinoma.HPSE and VEGF may be chosen as an important index to predict invasion and metastasis of pancreatic carcinoma.