Expression Of Ets-1 And Vascular Endothelial Growth Factor In Epithelial Ovarian Neoplasm And Its Clinical Pathological Significance

Background and objective We have already known that the independent growth and invasive metastasis are the main features of malignant tumor and terminal patients often died of the formation of lots of metastasis. Tumors of the ovary, especial the epithelial ovarian neoplasm, is one of the major lethal factors for women' health. Although the combined therapies of ovarian cancer are strengthening gradually, the mortality rate is still the first of gynecological malignant tumors. The main cause of death is the formation of metastasis, which is also the important factor related to the prognoses of patients.Angiogenesis is essential to the growth and metastasis of tumors, which is complicated and needs the involvement and mutual function of many elements, such as vascular endothelial growth factor(VEGF), which is the most important one, and its receptors, includes VEGFR-1 (Flt-1) and VEGFR-2(KDR) , many other associated factors such as matrix metalloproteinase(MMPs),urokinase plasminogen activator, (uPAs) and vascular endothelial cadherin(VE-cadherin) are also take part in the process of angiogenesis. These factors play important role in the differentiation of vascular endothelial cells, degradation of stromous and migration of endothelial cells. In recent years, the important function in the process of growth, infiltration and metastasis of solid tumors of Ets family, especial Ets-1, have drawn people's great attention, and Ets-1 has been considered as the promoting-tumor gene and the transcription factor of angiogenesis. In order to illuminate the mechanism of growth...