The Significance Of The Varitions Of Platelet Parameters In Cerebral Infarction Patients

Objectice:To study the regularity and significance of the variations of the platelet parameters in cerebral infarction during diffrence time and size.To assess the cerebral infarction patients pathogenetic condition prognosis roughly according to the platelet parameters.Method:The study selectes from the CI patients(CI group) who registered from october of 2008 to March of 2009 in the department Neurology of the first affiliated hospital in Guangxi Medical University and from the healthy physical examinees(control group) in the physical examination center in the same hospital and during the same interval.With regard to platelet study group:97 CI patient in experimental group,40 healthy examinees in control.In terms of time of incidence(in 48h 49h-7d 8-14d and after 14d) and infarct size(large size small size and lacunar CI),we separate the CI group into different subgroups,compare each subgroup with control separetely,and also make group comparison between platelet group,in order to approach the regularity and significance of the variations of the above-mentioned indexs.Result:The results show that:The PLT is the lowest in 48h after CI onset,but ascend gradually with the the time developed,and recovered to normal level at the 14 days post-currently(P＜0.05).Versus control group,MPV and PDW ascend markedly in 48h after CI onset(P＜0.05)and reach the peaks at the time of 48h-7d,then descend gradually,but even higher than control group at the recovery period(P＜0.05).The larger the infarct size is,the lower the PLT is, and the higher the MPV,PDW are;However,compare with control,PLT in Lacunar CI patientl has no significant difference(P＞0.05).Conclusion:We can assess the CI patients'pathogenetic condition prognosis roughly according to the platelet parameters.The CI patient who has the lower PLT and higher MPV and PDW,may suffer the larger infarct size,the condition may be more severe.Therapeutically,such patients should receive more dosage of anti-platelet drugs in the early stage,in order to improve prognosis and better theapeutic effects.Dynamic monitoring platelet parameters during the therapy may contribute doctors to master the patients'condition.