Effects Of Metabolic Syndrome On The Vascular Function In Patients With Essential Hypertension

Objective: To evaluate the effects of metabolic syndrome(MS) on the arterial function in essential hypertensive(EH) patients, support some valuable evidences to intervent earlier and reversal subclinical vascular disease in essential hypertensive with MS.Methods : 64 patients with hypertension were assigned into two groups: EH with MS group(EH+MS,n=32), EH without MS group(EH+nonMS,n=32). 31 healthy subjects was normal control(NC).Brachial-Ankle Pulse Wave Velocity (BaPWV) was measured using an automatic device (VP1000), Arterial elastic index(C1-large artery and C2-small artery )were measured by the CVProfiler-2020 pulse wave analysis instrument.Results:1. BaPWV in EH+MS and EH+nonMS was higher than that in NC. (1916.50±318.04,1757.59±313.90 VS 1517.93±314.97 cm/s, P<0.01 and <0.05);BaPWV in EH+MS was higher than that in EH+nonMS(P<0.05).2. The magnitude of C1 and C2 among three groups were: NC > EH+nonMS > EH+MS, (C1:11.32±4.62> 9.11±3.50> 6.66±3.11ml/mmHg×10, P <0.01;C2:5.05±2.44>3.55±1.95>2.53±1.16 ml/mmHg×100,P<0.05).3. Pearson Correlation show that BaPWV was significantly positive related with age(r=0.586),SBP(r=0.424),PP(r=0.529),TG(r=0.301)(P<0.01)and signifycantly negatively related with HDL-C(r=-0.401) (P<0.01);C1 was significantly positive related with HDL-C(r=0.241)(P<0.05 ) and significantly negatively related with age(r=-0.310),SBP(r=-0.539),PP(r=-0.588),TG(r=-0.322) (P<0.01); C2 was significantly positive related with HDL-C(r=0.392)(P<0.01)and significantly negatively related with age(r=-0.288),SBP(r=-0.480),PP(r=-0.486),TG(r=-0.302)(P<0.01).Conclusion:Metabolic syndrome may aggravate the dysfunction of artery in essential hypertensive patients.