Tacrolimus Versus Ciclosporin As Primary Immunosup-pression For Kidney Transplant Recipients: A Meta-analysis

Objective:To compare the acute rejection of tacrolimus and ciclosporin as initial treatment for renal transplant recipients.Methods:Searches were applied to the following electronic database:Medline, Embase Database,Cochrane Liberary.Randomized controlled trials comparing Tac with CsA for acute rejection after renal transplantation were included.Data were extracted independently by two reviewer.The methodological quality Was assessed by the Jadad Score.Statistical analysis were performed with Ravman 5.0.Result:217 papers were found,31 RCTs comparing Tac versus CsA for acute rejection after renal transplantation were identified.Meta—analysis show that the Biopsy-proven acute rejection,steriod-resistant acute rejection morbidity of Tac group Was lower than that of CsA group with statistical difference during half a year and 1 years.Conclusion:Compared with CsA,Tac represents lower post—transplant acute rejection incidence.