Studies On The Relationship Between Single Nucleotide Polymorphisms Of REG1A And Susceptibility To Gastric Cancer In Chinese Population

Objective To screen single nucleotide polymorphisms(SNPs) of REG1a gene in gastric cancer,explore the correlation of REG1a gene SNPs and gastric cancer.Materials and Methods To analysis SNPs of REG1a gene by applying PCR and DNA sequencing to 183 patients with primary gastric cancer and 204 healthy controls.Results We found 3 new SNPs in REG1a gene at site 929,1790 and 2751,and the differences of site 929 and 1790 were significant between gastric cancer patients and healthy controls(P＜0.05).Conclusions Sequencing of REG1a gene from specific population is available for screening candidate SNPs.The study reveals initially gastric cancer may be associated with site 929 and 1790.It provides a basis for further screening suitable SNPs labeling forecasting risk for gastric cancer.