| PurposeThe use of Danshen injection, Shenmai injection in treating acute cerebral infarction, stroke TCM in line with the blood disease resistance network cards, both by observing the clinical efficacy of TCM Syndrome points to change, change in neurological deficit score and blood flow the effects of rheology, the evaluation period of Salvia injection in treating acute cerebral infarction (stroke - blood stasis) whether the effect of the clinical efficacy superior to Shenmai injection and observe the safety to explore the mechanism of its efficacy, to explore whether the intravenous drug of Chinese medicine Differentiation drug to the election.Methods1. 60 cases of all cases of patients with acute cerebral infarction in June 2008 the Department of -2009 Chinese medicine hospital in Hubei Province in March neurology out-patient and in-patient treatment of patients, Chinese medicine is a dialectical stasis disease resistance network cards, A randomized, parallel-controlled methods, according to the ratio of 1:1, is divided into Danshen injection group (hereinafter referred to as SM group) and Shenmai injection group (hereinafter referred to as Shenmai group), 30 cases of each group and followed by administration. Danshen Danshen injection group (Qingchunbao Zhengda Pharmaceutical Co. , Ltd., batch number Z33020177), Shenmai Shenmai injection group (Hebei Shenwei Pharmaceutical Co., Ltd., batch number Z13020886), SM group: Danshen injection 3 0ml solution by adding 0. 9% sodium chloride injection 250ml of intravenous drip, once a day. Medication for 14 days. Shenmai group: Shenmai injection 40ml by adding 0. 9% sodium chloride injection 250ml of intravenous drip, once a day. Medication for 14 days, with no leading-in period. The course of treatment based on two sets of cases are related to the treatment and symptomatic treatment. But does not test the use of similar drugs in Chinese medicine; do not use drugs or nutrition metabolism of brain protective agents, cerebral metabolism activator.2. Safety tests before and after that first visit in the treatment and medication the first day of the first 14 days of the first laboratory tests done to blood, urine, stool routine, liver and kidney function, blood prothrombin time, fecal occult blood examination, blood rheology, ECG, head CT or MRI as a safety indicator, in order to observe whether the two groups of toxic drugs, side effects.3. That first visit before and after treatment and medication the first day of the first 14 days of the observation points a stroke, stroke symptoms score, the degree of neurological deficit score, and patients with a total capacity of the state of life score, and do statistical analysis to compare Dan Shenmai injection and theclinical efficacy of injection.Results1. Stroke patients to determine efficacy analysis: the treatment of clinical recovery after the SM group number 2, effective number of eight cases, the effective number of 15 cases, total effective rate was 76. 7%; Shenmai the number of group 7 cases markedly effective, 13 the number of cases, total effective rate was 66. 7%. By Ridit test, two groups of effects were significantly different (P <0. 05). Description Danshen injection on the improvement of stroke symptoms significantly promote.2. Evaluation of efficacy of TCM Syndrome: Danshen group markedly after treatment the number of eight cases, the effective number of 15 cases, total effective rate was 76. 7%; Shenmai markedly the number of group 9 cases, 13 cases of the effective number, the total effective rate 70% . by Ridit test, two groups of effects were significantly different (P <0. 05). Description of Chinese medicine Danshen injection have a significant effect on symptom improvement.3. Clinical neurological deficit scores to determine: Ridit tested by the two groups were significantly different (P <0. 05), with excellent Danshen group.4. Hemorrheology improvement compared: the two groups can improve the blood rheology indicators in order to better Danshen group.5. Safety Testing: The security detection, treatment group patients were observed before and after the blood, urine, stool routine, liver and kidney function, blood prothrombin time, fecal occult blood examination, hemorrheology, electrocardiogram, showed two group of non-toxic drugs, side effects, the use of safe and effective and reliable.ConclusionDanshen injection treatment group and control group Shenmaiinjection of Chinese medicine to acute cerebral blood dialecticalresistance network of stroke patients with disease points todetermine efficacy, efficacy of TCM Syndrome points, clinicalefficacy of neurological deficits points, hemorheology improvementcompared by statistical analysis were significantly different (P<0. 05). SM group and the group is better than Shenmai. Descriptionof TCM Syndrome Differentiation of intravenous drug is to choosedrugs, at the same time as the safety inspection, show that twogroups of non-toxic drugs, side effects. Because only 60 cases ofpatients, remains to be further clinical observation.
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