| PurposeSpinal cord compression is frequent affection of nervous system.Multitude reasons can induce the compression and damage of spinal cord,for example,the degenerative disease of antisternum and disci intervertebrales,intraspinal tumor,the surgical trauma of backbone,spinal tuberculosis and affection with transmissibility and congenita spinal deformity and so on.Its clinical symptom is obvious and it effects the patients'quality of life acutely.Now,magnetic resonance imaging is conventional means diagnosing spinal compression and damage in clinic work.But because MRI only displays morphous change of compressed spinal cord and doesn't display spinal early changes of molecular leve,its sensitivity is lower.Diffusion tensor imaging is a kind of new technique after diffusion weighted imaging.DTI can reflect anisotropy hydrone molecular diffusion features of damaged myeloid tissue through measuring apparent diffusion coefficient and fractional anisotropy.Accordingly,we can make more precise and allround estimate about spinal compression on microscopic scale.The aim of our study is to explore 3.0T DTI can discover wether or not early degeneration changes and damages of white substance of spinal cord which routine examination can't discover.And to approach DTI appearances of different spinal compression degree and its clinical application value in spinal cord compression.Materials and MethodsRoutine MRI and axial DTI was performed in 42 cases of spinal cord compression and 40 cases of healthy volunteers.DTI scanning deploys master single test provocation-spin echo plane echo imaging sequence.Diffusion weighting coefficient b=700s/mm2;Diffusion saitivity gradient is in six different directions;SENSE factor is 0;Revetition time=4000ms,Echo time=56ms;Sheet thickness is 3mm;Sheet interval is 0;Field of view is 230mm;Collection matrix is 128×128;Collection frequency is 2; Scanner time is from1′45″to 4′07″.There are 15 second degree compression,14 third degree compression and 13 fourth degree compression.PHILIPS PRIDE reconstruction package adopted each study the FA map.We choose regions of interest at the image of b=0 and measure fractional anisotropy.Regions of interest are round or ellipse and size is about 10～20 mm~2.The value of fractional anisotropy(FA) was respectively measured in region of interests(ROI) of case group and control group on FA maps and FA value was compared in order to observe if difference exists in two groups.We deploy SPSS13.0 statistical package to carry out statistics analysis and all measurements are demonstrated into mean and standard deviation.There exists statistic difference when p＜0.05.ResultsImaging of abscissa axis of all subjects can clearly display myeloid tissue and there is no evident twist and deform of imaging.In healthy volunteer group,FA values have no statistic difference at different segment myeloid tissue.FA values at location of spinal cord compression and its forthcoming location(No abnormality was found on morphous and signal of T2-wighted imaging)were reducing compared with control group(p＜0.01). There are statistic differences in FA values of different compression degree.FA values of three degree compression decreased compared with two degree compression(p＜0.05);FA values of four degree compression were reducing compared with three degree compression(p＜0.01).ConclutionDTI may be more sensitive in pristine wallerian degeneration of spinal cord compression and can reflact the degree of injury of spinal cord compression.DTI is more precise checking method and can provide valuable information of quantization for earlier diagnosis of spinal cord compression in vivo.
|
PDF Full Text Request