Dynamics Research For Thrombosis And Vascular Interventional Treatment

Influence from thrombus formation and the intervention therapy are simulated numerically in this paper. One of the main research directions is to simulate the blood flow in various vessels, which studies the factors influencing the thrombus formation from the points of Computational Fluid Dynamics. On the other hand, interventional operation through bypass grafting and thrombus dissolution is simulated in order to find the best way for bypass grafting and best results of thrombus dissolution.For the blood flow simulation in various vessels, the influence from existent thrombus on the possible thrombus formation later and the influence from blood flow on thrombus formation in curving vessel and T-bifurcation or Y-bifurcation are analyzed. Researches indicate that in straight vessel there will be a series of"apt-for-thrombus"locations after the existent thrombus. These locations satisfy the physical qualifications for thrombus formation, thus, once the thrombus appears, a series of thrombus probably come out even to build jam in the vessel. For the curving vessel, the"apt-for-thrombus"locations will correspondingly be at the inner wall of the curvature. As for T-bifurcation and Y-bifurcation, some"apt-for-thrombus"locations concentrate near the bifurcation. All the simulation results accord compltetly with the statistical results about the thrombus locations in clinic treatment.In the simulation of bypass grafting therapy, it numerically computes the bypass grafting in coronary artery with various blockage ratios. By analyzing the blood flow velocity field, wall shearing stress and wall pressure, whether it is reasonable to take an operation as long as thrombus appears, is discussed here. Also, after studying the effects of bypass with various blockage ratios and the interference of thrombus to blood flow, it concludes that the larger the blockage is, the better the effects of the bypass grafting operation are. Of course, on this occasion the section of vessel between thrombus and bridge will basically evolve into backwater, which means that this part might come into complete blockage and lose its function.For three dimensional simulation of interventional thrombus dissolution, by changing the injection velocity of medical solution and comparing the real usage of the solution, the best location for injection is ascertained at the area between 3mm away upstream and 2mm downstream and the appropriate velocity is between 0.35-0.60m/s, which is enough to achieve the purpose of thrombus dissolution.The combination of multi-disciplines knowledge including Computational Fluid Dynamics (CFD), Clinical Medicine and Anatomy etc is applied to simulate thrombus formation and interventional therapy. Combined with the validation provided by clinical cases and anatomy researches, the reasons for thrombus formation from hydrodynamics'view are given. The simulation results of the thrombus formation and interventional therapy could supply the clinical treatment with some guidance.