| Objective:To investigate the effects of hydroxyethyl starch 130/0.4 on the level of serum albumin and inflammation mediators during major abdominal surgery,and research hypo-albumin emia mechanism postoperatively.Methods:Thirty patients scheduled for elective abdominal surgery were randomized to receive either hydroxyethylstarch or partes acquales balanced solution.All patients which were divided into the control group and the HES group,They included 2 cases of abdominal tumor radical correction,5 cases of biliary tract and intestinal tract Anastomosis,3 cases of pancreas and intestinal tract anastomosis,3 cases of pancreas and duodenum excision,7cases of lobes of livers excision and intestinal tract exploration.Serum concentrations of albumin,IL-6,TNF-αwere measured twelve hours before operation or after the end of surgery,as well as 24 hr,48 hr and 72 hr.The operation time and blood loss volume were recorded at the end of surgery.Results:1.The ALB content of control group and HES group postoperatively was lower than preoperatively,There was no significant differerence in the preoperative and postoperative 12 hr,The ALB content of control group was higher than HES group postoperatively.2.The CRP of control group and HES group postoperatively was higher than preoperatively.There was no significant differerence in the preoperative and postoperative 12 hr and 72 hr between two groups.The level of control group was lower than HES group postoperatively.3.The IL-6,TNF-αof control group and HES group postoperatively were higher than preoperatively.There were no significant differerence in the preoperative and postoperative 12 hr between two groups.The level of control group was lower than HES group postoperatively.Conclusion:1.The ALB content of patients after surgery was cut down,but inflammation mediators was heightened,which sharply reflected in the postoperative 48 hours.2.Using hydroxyethylstarch 130/0.4 have apparent effects on the level of ALB contents and inflammation mediators.
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