The Prognostic Analysis Of Chemotherapy Followed By Surgery For Patients With Colon Cancer

Objective: To evaluate the prognostic analysis of oxaliplatin-based chemotherapy followed by surgery for patients with colon cancer,and provide some theoretical guidance for assessing the clinical efficacy of colon cancer.Methods: Ninety-two patients of colon cancer receiving oxaliplatin-based chemotherapy followed by surgery in our department were analyzed from Jan,2003 to Dec 2007.The survival rate was estimated by Kaplan-Meier method.The prognosis factors were analyzed by univariate(log rank) and multivariate(Cox mode) analysis methods.Results:(1)The 1-,3-and 5-year overall survival rates were 82%,71% and 59%。(2)The univariate analysis showed that age,performance status, pathological differentiation,the number of lymph nodes,metastasis and clinical stage were statistical significance for poor prognosis,and there were differences of≥3 grade toxicity between performance status 0～1 and 2. In multivariate analysis,age, performance status and the number of lymph nodes were comfirmed as independent prognostic factors,among them,age was a protective factor.Conclusion: Some prognostic factors are associated with the prognosis.Age, performance status and the number of lymph nodes was associated with poor prognosis.