To Analysis The Relationship Between Helicobacter Pylori Infection And Non-Steroidal Anti-inflammataory Drugs In Peptic Ulcer

Objective:To be clear about whether H.pylori infection and NSAIDs use is in coordination with each other in peptic ulcer and bleeding peptic ulcer.Methods:There was a case-control study between two groups.The peptic ulcer groups consisted with 103 peptic ulcer patients who were diagnosed with endoscopy,the non-peptic ulcer groups consisted with 233 patients.The patients of these groups were both admitted to The First Hospital of Shanxi Medical University in the some time from 2006.5 to 2008.11.We analyzed the difference of NSAIDs use history and the H.pylori infection status between this two groups and between the 45 patients with gastrointestinal hemorrhage and 58 patients without gastrointestinal hemorrhage in the peptic groups.We get the OR value and the 95%C.I of the exposed factor(H.pylori infection;NSAIDs use) to peptic ulcer with mono-agent and multi-agent analysis.Results:mono-agent analysis shows the OR value is 2.117 and 8.256 in gastric ulcer and duodenal ulcer patients of H.pylori infection;and the OR value is 5.982 and 2.796 in gastric ulcer and duodenal ulcer patients of NSAIDs use.But with multi-agent analysis,the relationship between H.pylori infection and NSAIDs use in peptic ulcer shows the OR value is 1.786 and 9.598 in gastric and duodenal ulcer patients of H.pylori infection purely.The OR value of gastric and duodenal ulcer is 14.815 and 30.556 in patients who had the history of NSAIDs use complicating H.pylori infection,it's much higher than the add of H.pylori infection and NSAIDs use respectively purely.The study on H.pylori,NSAIDs use and peptic ulcer with mono-agent analysis shows the OR value is 1.067 and 0.862(95%C.I 0.159-4.660) in the gastric and duodenal ulcer bleeding patients with H.pylori infection respectively,and the OR value is 3.054 and 0.974(95%C.I 0.284-3.338) in the gastric and duodenal ulcer bleeding patients of the history of NSAIDs use individually.But with multi-agent analysis shows the OR value is 0.769(95%C.I 0.137-4.328) and 0.870(95%C.I 0.112-6.751) in the bleeding gastric and duodenal patients of purely H.pylori infection,the OR value is 2.000 and 2.727 in bleeding gastric and duodenal ulcer patients of purely NSAIDs use;The patient's OR value of bleeding gastric ulcer who had the the history of NSAIDs use complicating H.pylori infection is 2.800,higher than the add of NSAIDs use and H.pylori infection,but the OR value of bleeding duodenal ulcer who had the history of NSAIDs use and H.pylori infection is 0.833(0.084-8.240),lower than the add of NSAIDs use and H.pylori infection respectively purely.The study of the risk between ulcer bleeding and time of NSAIDs use finds,the OR value of suffering ulcer bleeding in occasional,frequently and long-term administrated patients is 4.000,5.000 and 5.000 respectively.There is no significant difference in every groups.Conclusion:H.pylori infection and NSAIDs use can increase the risk of peptic ulcer,and NSAIDs use is in coordination with H.pylori infection in gastric and duodenal ulcer morbidity.Both NSAIDs use and H.pylori infection purely can increase the risk of bleeding gastric ulcer,but neither of them can increase the risk of bleeding duodenal ulcer,and NSAIDs use is coordination with H.pylori infection in bleeding gastric ulcer,but it isn't coordination with H.pylori infection in bleeding duodenal ulcer.NSAIDs use lasting different days can increase the risk of bleeding peptic ulcer obviously,but the risk of bleeding peptic ulcer is not different in the patient of occasionally,frequently and long-term NSAIDs use.