The Study On Relationship Between The Biological Behaviors Of Lung Cancer And Tumour Markers Cyfra21-1, ProGRP, NSE And CEA.

Objective:To study the relationship between on cyfra21-1 proGRP NSE CEA and biological behavior of lung cancer.To explore the clinical value of them on the diagnosis and effective detection and prodnostic evajuation of lung cancer.Methods:150 cases of lung cancer, 50 cases of benign disease and 50 cases of health adults were enrolled in our study.â‘ The results of the level from serum and venous blood of four tumor markers detected by method of ELLISH were statistically analyzed.â‘¡The changes of level before and after two cycle chemotherapy of different biological markers in 70 cases from our groups were analyzed.â‘¢The prognosis of 33 cases of lung cancer who more than 12 monthsSurvival and 22 cases with less than 6 months were studied.â‘£The levels of four tumor markers in venous blood and pleural effusion from 50 cases of lung cancer and 30 cases of benign lung disease were detected. At the same time, we conducted the exfoliation cytological examination of those malignant lung diseases. Statistical analyses were performed using SPSS 13.0 software package.Results:1. The positive rates of serum cyfra21-1 ProGRP NSE and CEA in cases of lung cancer were significantly higher than other two groups (P<0.001).2. The level of four tumor markers was also significantly higher than other two groups (P<0.001).3. The levels of four tumor markers in serum are significantly different among different pathetical types. The levels of Cyfra21-1 in squama cels carcinoma were the highest among three pathological types. NSE and ProGRP, the SCLC caught the highest levels. While the highest level of CEA belonged to the adenocarcinoma (P<0.01).4. The serum levels and positive rates of Cyfra21-1 ProGRP NSE CEA were associated with clinical stages. With the increasing of clinical stages, the level of those four tumor markers also increasing.5. The age sex and state of smoking showed no statistical significant with tumor marker levels.6. The level of Cyfra21-1, ProGRP, NSE and CEA were associated with the treatment results. The level of patients achieving PR or CR after treatment was decreasing (p<0.05). 7. The serum level of Cyfra21-1 ProGRP NSE CEA was also associated with the patients prognosis (p<0.001). The tumour marker level was significant higher in patients with survival time less than 6 months than in patients with survival time more than 12 months. And that the survival rates more than 12 months was higher in patients with normal level of Cyfra21-1 ProGRP NSE CEA than in patients with higher tumour levels.8. For levels of effusion, all of the four tumour markers show higher level in lung cancer than in benign disease. Among them, Cyfra211 and CEA were showed the most remarkable (p<0.05).9. The area blow ROC curse put their largest one to CEA, The second was given to Cyfra21-1, The coincidence probability of these two tumour marker with the results of cytology got 100%.Conclusion:1. The serum level of Cyfra21-1 ProGRP NSE CEA was greatly associated with the biological behavior of lung cancer, the expression of Cyfra21-1 in squaous cells carcinoma, NSE and ProGRP in SCLC and CEA in adenocarcinoma were higher than other pathology types. The progress level is related with the clinical stage and prognosis.2. It shows the monitoring value in progress of treatment that the relationship between the change of four tumour markers and treatment results. With the decreasing of tumour marker levels, patients may get a better survival time.3. It shows great value for differenting from benign and malignant pleural effusion, for dignosis of pathology type by detecting the levels of Cyfra21-1 ProGRP NSE CEA.