Effect Of Metabolic Syndrome On Abdominal Obesity, Artery Atherosclerosis, Peripheral Arterial Disease

Objective: To investigate whether metabolic syndrome (MS) has an effect on abdominal obesity, artery atherosclerosis, peripheral arterial disease.Methods: 194 physical examinees in the health examination department of Liuzhou People's Hospital were selected to enter the study, according to 2005 IDF worldwide consensus definition of MS Chinese standards, all participants were divided into the MS and non-MS group, each group included 63 cases and 131 cases respectively. Anthropometic and metabolic parameters, brachial-ankle pulse wave velocity, ankle-brachial index, abdominal subcutaneous fat thickness and visceral fat thickness via ultrasonography were measured.Result: (1) Independent sample t-test domonstrated that WT, BMI, WC, HR, SBP, MAP, DBP, PP, FPG, FPI, HOMA-IR, CRP, TC, TG, ApoB, SFT, VFT, baPWV were significantly higher in the MS group than in the non-MS group (p<0.05 for all), while HDL-C, ABI were significantly lower in the MS group than in the non-MS group (p<0.05 for all), AGE, HT, LDL-C, ApoA1, Apoα, CR, UN, UA level did not differ in the two groups (p>0.05 for all); (2) Bivariate correlation analysis showed that VFT correlated with WT, WC, BMI, SFT, TC, TG, UA, SBP, MAP, DBP positively (p<0.05 for all), correlated with HDL-C, CR, UN negatively (p<0.05 for all); baPWV correlated with AGE, HR, SBP, MAP, DBP, PP, FPG, HOMA-IR, LDL-C positively (p<0.05 for all), correlated with WT negatively (p<0.05 for all); ABI correlated with AGE, SBP, MAP, PP positively (p<0.05 for all), correlated with BMI, HR negatively (p<0.05 for all). Stepwise regression analysis showed that WC was an independent determinant factor of VFT; and AGE, SBP, FPG were independent determinant factors of baPWV. (3) The prevalence of abdominal obesity, artery atherosclerosis, peripheral arterial disease in the MS group was 42.9%, 23.8%, 14.3% respectively, the corresponding prevalence in the non-MS group was 13.7%, 6.9%, 3.1% respectively, the prevalence of the three diseases in MS group was significantly higher than in the non-MS group (p<0.000, =0.001, =0.009 respectively). (4) Receiver operating characteristic curve analysis showed that the AUC of VFT predicting MS, in female was 0.734 (95% CI 0.610-0.858; p=0.003), diagnostic sensitivity 70.0%, specificity 62.9%, diagnostic cutoff value was 47.2mm; in male was 0.718 (95% CI 0.574-0.862; p=0.005), diagnostic sensitivity 73.9%, specificity 65.0%, diagnostic cutoff value was 52.5mm. The AUC of baPWV predicting MS, in female was 0.899 (95% CI 0.826-0.972; p<0.000), diagnostic sensitivity 90.0%, specificity 76.9%, diagnostic cutoff value was 1391cm/s; in male was 0.717 (95% CI 0.582-0.852; p=0.006), diagnostic sensitivity 91.3%, specificity 57.6%, diagnostic cutoff value was 1385cm/s.Conclusion: VFT, baPWV, ABI associates with MS components closely. The existence of MS significantly promotes the accumulation of visceral fat and increases risk of artery atherosclerosis and peripheral arterial disease. Increased visceral fat accumulation and elevated brachial-ankle pulse wave velocity both are good predictors of MS.