Impact Of Maternal High Fat And High Calorie Diet On AS Of The Offspring In Rats

Objective:To observe the impact of maternal high fat and high calorie diet on AS of the offspring in rats.Methods: 20femal rats were grouped two groups, high nutrition group (G) and common diet group (P). Pregnant rats were fed with high fat and high calorie diet and common diet respectively duration of pregnancy. The male offspring of G group were divided into two groups, high nutrition group (G-G) and common diet group (G-P), and the male offspring of P group were still feed common diet. Then the Oxidation-low density lipoprotein (OX-LD), Triglyceride(TG),Total Cholesterol(TC), Highdensity lipoprotein-cholesterol (HDL-C) and Low density lipoprotein-cholesterol (LDL-C) concentrations in serum were measured and observing the lipoid deposited in aortas which were dyed by HE at the end of 12 weeks.Results:â‘ T he OX-LDL, TC and LDL-C concentration :the G-P and G-G groups are significantly higher than the concentration of P-P group(P<0.01);The G-G group is higher than the G-P group (P<0.05).â‘¡The concentrations of TG and HDL-C are no difference in all groups (P<0.05).â‘¢The rate of offspring aortas fatty streak appearances in G-G group is the highest ,and G-P group is the second, and the P-P group is the lowest.Conclusions: Maternal high nutrition has great impact on AS of the offspring, and the offspring common diet can delay or prevent the occurrence of AS.