The Relationship Of Blood Levels In Leptin, Insulin-like Growth Factor1, Lipid With Fetal Growth And Development

Objectives The aim of the study was to explore the association of blood levels of leptin,insulin-like growth factor1and lipid with fetal growth and development, and analyze thecorrelation between maternal serum leptin and leptin in umbilical blood, maternal seruminsulin-like growth factor1and insulin-like growth factor1in umbilical blood, maternalserum blood lipid and blood lipid in umbilical blood by detecting the levels of leptin,insulin-like growth factor1and blood lipid in maternal venous blood and umbilical venousserum as well as measuring the birth weight, body length, head circumference, chestcircumference and abdominal circumference of neonates.Methods90cases of neonates and pregnant women without any gravidity comorbidityor complications from November2011to March2012were selected, who were due todeliver at the Hebei United University Affiliated Hospital Department of Obstetrics. Elbowvenous was extracted from the pregnant woman pre-labor and also extracted the umbilicalvenous blood after the baby was delivered and before the placenta was delivered, thenseparated the serum. RIA was performed on the maternal and umbilical blood to determinethe blood leptin. RIA was used to detect the level of insulin-like growth factor1inmaternal blood and umbilical blood. A fully automatic biochemical analyzer was used toassay the level of TG, CHOL, LDLC and HDLC in the maternal and umbilical cord blood.The Newborn’s weight was measured with an electronic weighing instrument. Body length,head circumference, chest circumference and abdominal circumference were measuredwith a metering band. SPSS13.0software was used for statistical date analysis.Results1The general information of the research objects. The study selected90cases ofpregnant women whose average age was26.55±3.42years old, ponderal growth duringpregnancy was18.49±4.64kg, and pre-pregnant BMI was20.94±2.95. The study alsoselected90cases of neonatus. Their mean gestational age was39.70±1.10weeks, birthweight was3418.60±469.36g, body length was50.04±1.45cm, head circumference was33.78±1.33cm, chest circumference was34.53±1.55cm, and abdominal circumferencewas34.27±1.42cm. Among them,58cases were male and32cases were female.50caseswere cesarean section and40cases were vaginal delivery.2There was positiverelationship between the birth weight, body length, head circumference, chest circumference, abdominal circumference of neonatus and leptin level in umbilical blood(P<0.05, respectively).3The birth weight, body length, head circumference, chestcircumference, abdominal circumference of neonatus had positive correlations with thelevels of IGF-1in maternal blood and umbilical blood (P<0.05, respectively).4There wasno relationship between the birth weight, body length, head circumference, chestcircumference, abdominal circumference of neonatus and levels of CHOL in maternalblood and umbilical blood (P>0.05), but a positive correlation was found between placentaweight and the level of CHOL in maternal blood (P<0.05, respectively), however there wasno relationship between the LDLC and HDLC in maternal blood (P>0.05, respectively).It had no relation between the body length, head circumference, chest circumference,abdominal circumference and the CHOL level in maternal blood(P>0.05, respectively).The neonatal birth weight, length, head circumference, chest circumference, abdominalcircumference were not connected to the levels of TG, CHOL, LDLC, HDLC in umbilicalblood (P>0.05, respectively).5Multiple regression analysis. Both neonatal anthropometricindexes had positive correlations with the LP in umbilical blood (P<0.05).6The levels ofLP and IGF-1in maternal blood were significantly higher than those in umbilical blood(P<0.05, respectively), and the levels of TG, CHOL, LDLC, HDLC in maternal bloodwere obviously higher than those in umbilical blood (P<0.05, respectively).7There wasrelationship between the level of leptin, insulin-like growth factor1, total cholesterol inmaternal blood and that in umbilical blood.But the levels of, TG, LDLC, HDLC inmaternal blood were not connected to those in umbilical blood (P>0.05, respectively).Conclusions1Umbilical blood LP plays an important role in regulating the process offetal growth and development. After multiple regression analysis it was observed to have avery significant effect.2Maternal venous blood IGF-1、CHOLand that in umbilical bloodplay an important role in the regulation process of fetal growth and development.3TG,CHOL, LDLC, HDLC in maternal blood and umbilical blood come from different sources,they have their own independent production and regulation system.