Preparation Of Nano-fluorouracil-coated Intraocular Lens And Empirical Study On Its Inhibiting Posterior Capsule Opacification

Objective To prepare nano-fluorouracil-coated intraocular lens( IOL ) and to investigate its effect and feasibility of inhibiting posterior capsule opacification ( PCO ) of rabbit.Methods Nano-fluorouracil is cross linked with IOL with the technology of energy-loaded particle beam. Forty New Zealand white rabbits were medially divided into 2 groups named group A and B randomly. All the crystalline lens of the left eyes were emulsified and evacuated of by the same operator, and then different treatment in different groups. In group A, the control group, the Polymethylmethacrylate (PMMA) IOLs were implanted. In group B, the nano-fluorouracil-coated IOLs were implanted. Slit-lamp-micrographscopy, histopathologyscopy and electron-microscopescopy were performed when 4 weeks after the operations.Results The incidence rate and severity degree of PCO in control group is higher than the other group. The inflammatory reaction of anterior segment of the left eyes were remarkably occurred in group A. While almost no inflammatory reaction of anterior segment of the left eyes occurred in group B.Conclusions With implanting nano-fluorouracil-coated IOLs after phacoemulsification and evacuation of the crystalline lens can inhibit PCO actively and have slight toxic reaction and damage in the eyes.