Comparison Of The Outcome And Safety Of ICSI By Different Origin Of Sperm

OBJECTIVE:To study the outcome and safety of ICSI by different quality and sources of the sperms.METHODS:One thousand two hundred seventy-five patients who underwent 1295 ICSI cycles were evaluated retrospectively.Patients were divided into six groups according to the quality and sources of sperms.Group 1 is composed of 89 cycles of ICIS in 88 patients with relative normal semen parameters.Group 2 is 209 cycles in 207 patients with mild oligo-astheno-teratozoospermia(OATS).Group 3 is of 672 cycles in 667 patients with severe OATS(SOATS).Group 4 is of 108 cycles in 103 patients with extremely severe OATS(ESOATS).Group 5 is of 177 cycles in 172 patients using testicular or epididymal sperms.Group 6 is of 42 cycles in 41 patients using frozen-thawed sperms.RESULTS:(1)The fertilization rate gradually reduced with decreased semen quality, and it was significantly lower in Group 4(71.3%)and Group 5(66.0%)than other 4 groups(P＜0.05).(2)The cleavage rate was significantly lower in Group 5 (95.8%)(P＜0.05).(3)The clinical pregnancy and implantation rates were significantly lower in Group 2(P＜0.05),and there were no significantly differences in other 5 groups (P＞0.05).(4)The rates of chemical pregnancy,multiple pregnancy,implantation, miscarriage,live-birth and premature birth,as well as weeks of premature birth,weight of newborns,low birth weight and sex ratios(males/males+females)were no significantly difference in all 6 groups(P＞0.05).(5)There is one boy with hypospadias in G2;and(here are three boys with congenital cardiopathy,hypospadias,hexadactylism respectively,and one girl with megacolon in G3.CONCLUSION:Different origin and different parameter of sperm can mainly affect the fertilization and cleavage,with no affect to the implantation,miscarriage nor the newborns.The assessment of malformation of offspring should increase sample size to further study.