The Clinical Characteristics Of Hypothyroid Myopathy

Objection:The study was to investigate the clinical characteristics and diagnosis of hypothyroid myopathy.Methods:1,The 2 cases with hypothyroid myopathy are collected from patients in department of neurology since 2006.2,The related literatures in recently years are reviewed and analysed.Results:Hypothyroid myopathy is characterized by muscle aches,muscle pain,stiffness, proximal weakness,fatigue,cramps,slowed movements and reflexes,myxedema and hypertrophy.The two patients both had symptoms and signs of hypothyroidism,such as myxedema,high cholesterol.One patient complains of cramps and pain in the muscles of the shoulder and pelvic girdle,which increase with movement.The other' myopathy is proximal weakness.In these patients,laboratory tests indicated markedly elevated serum muscle enzymes(especially CK) and lipids,low free triiodothyronine and free thyroxine levels.Anti-Jo-1 autoantibody of these patients were both negative. Electromyographic evaluation did not show typical myopathy.Oral L-thyroxine treatment was started and at 1-2 months follow-up examination,mental status and physical performance were improved.Conclusion:Because patients with hypothyroid myopathy have a good prognosis after L-thyroxine treatment,we should be think highly of this disease.Thyroid function tests are necessary.