The Validity Of Pulmonary Vascular Permeability Index In Diagnosing Acute Respiratory Distress Syndrome

Object To validate pulmonary vascular permeability index derived from pulse contour continuous cardiac output(PiCCO) variables in diagnosing acute respiratory distress syndrome.Method 16 patients with acute respiratory failure and receiving mechanical ventilation support were enrolled between June 2006 and May 2007 in the Intensive Care Unit of 2nd Affiliated Hospital,Zhejiang University,College of Medicine.With PiCCO monitoring,Extravascular Lung Water(EVLW),Global End-Diastolic Volume(GEDV),Intrathoracic Blood Volume(ITBV) and Pulmonary Blood Volume(PBV) were collected and then Pulmonary Vascular Permeability Index (PVPI) was calculated and analyzed.Result 5 cases of the patients were found to have increased PVPI(＞3 percent),among which 4 cases were diagnosed as ARDS according to the criteria of the American-European Consensus Conference in 1994.The specificity and sensitivity of PVPI on diagnosing ARDS in this study were 83.3 percent and 75 percent,respectively.Conclusion The Pulmonary Vascular Permeability Index (PVPI) derived from PiCCO measurement may have value in diagnosing ARDS,but more data should be collected to approve the validity.