Acute Phase Postprandial Hyperglycemia Affects The Short-term Prognosis Of Cerebral Infarction

Background: It is a known fact that hypertension and diabetes are independent risk factors of cerebrovascular disease. The relation between postprandial hyperglycemia and cerebrovascular disease has not been cleared. Many scholars prove that postprandial hyperglycemia may have impacts on endothelial cell function, hemorheology, part of the release of inflammatory factors, and increase the incidence of cerebrovascular disease risk, so early intervention of postprandial hyperglycemia in non-diabetic population, strictly control of postprandial hyperglycemia in patients can control and change the natural course of disease and reduce the incidence of cerebrovascular disease. But few people study and analysis postprandial hyperglycemia in the acute phase play an important role in the short-term prognosis of patients with cerebral infarction. The multiple Logistic regression analysis was used to evaluate the associations between the risk factors and the outcome. It is stressed that the influence of postprandial hyperglycemia on the pathogenetic condition and prognosis of cerebral infarction. In general, we must do as much as possible on the postprandial blood glucose controlling in the treatment of cerebral infarction. It is important to make the postprandial blood glucose meet standard and avoid severe hypoglycemia. At the same time, effective intervention measures for multiple risk factors (dyslipidemia, hypertension, HCY, Fg, etc.) must strengthened to minimize, delay the occurrence of complications. This would improve quality of life, reduce medical costs and extend the healthy life span.Object: The aim of this study was to analysis the influence of postprandial hyperglycemia on the pathogenetic condition and short-term prognosis of cerebral infarction.Methods: We measured the postprandial glucose of 101 cases with cerebral infarction, and then divided into two groups of postprandial hyperglycemia and normal postprandial glucose. We observed the damage degree of nerve function and ability of in dependent life. The multiple Logistic regression analysis was used to evaluated the associations between the risk factors and the outcome.Results: The level of postprandial glucose was positively correlated with the score of NIHSS (rs=0.327; P=0.001). At 4th, 12th and 24th week after cerebral infraction, the difference between the two groups in scores of NIHSS and BI was significant (P<0.05). The multiple Logistic regression analysis demonstrated that higher postprandial glucose was an independent predictor of death or new vascular event (OR 7.772;95%CI 1.075～56.189;P=0.042).Conclusion: The short-term prognosis of postprandial hyperglycemia group is worse than that of normal postprandial glucose group. Postprandial hyperglycemia may be an independent predictor of death or new vascular event. Objective: To investigate the feature of plasma Homocysteine (Hcy) level of patients with acute cerebral infarction and the related factors.Methods: 112 patients with acute cerebral infarction and 56 control subjects were recruited. Plasma level of Hcy was assayed by high-performance liquid chromatography (HPLC). The level of Hcy of patients with acute cerebral infarction and its related factors were analyzed by SPSS 12. 0.Results: The mean plasma level of Hcy in patient group was significantly higher than that of the control group ( P < 0.05). The standardized regression coefficients in regression equation of Hcy for gender and folic acid level were– 0.285 and– 0.227 respectively.Conclusion: The increase of plasma Hcy level might be one of risk factors of cerebral infarction; and the gender and level of folic acid were the factors influencing plasma Hcy level.