Observation Of Curative Effect Of Recombinant Human Granulocyte-Colony Stimulating Factor For Children Infection Associated Neutropenia

Objective:Adopted the principle of clinical test with sequential design, summarized the clinical data of Infection Associated Neutropenia in children who met the inclusion criteria; Evaluated curative effect of rhG-CSF for Children Infection Associated Neutropenia.Methods:Infection Associated Neutropenia children who met the inclusion criteria visited our hospital during Feb, 2007 ~ Jan, 2009 were statistically analyzed in clinical data; All the patients were treated with rhG-CSF once, subcutaneous injection of 5μg/kg after admission, Observed improvement in clinical symptoms, reexamined the blood routine, evaluated curative effect of rhG-CSF and monitored the adverse reactions at the following day or the next day after admission.Results:(1) Accordance with the inclusive and exclusive criteria, we collected 102 children in our hospital during Feb, 2007~Jan, 2009, patients with virus positive occupied 55(53.9%), mycoplasma positive occupied 28 (27.5%), mycoplasma complicated by virus infection occupied 8(7.8%); 58 cases did throat swab culture, 6 cases(10.3%) positive; 85 cases did the c-reactive protein examination, 18 cases (21.2%) increased at different degree; 52 cases took the chest X-ray examination, 21 cases (40.4%) appeared abnormal.(2) Cases of this group, neutrophil deficiency occupied 20 (19.6%), 26 of them (15.7%) were accompanied by anemia, 6 cases (5.9%) with thrombocytopenia.(3) Cases of this group, primary diseases were infection, there were 41 cases with upper respiratory tract infection (40.2%), 22 cases with bronchitis (21.6%), 21 cases with pneumonia (20.6%), 7 cases with diarrhea (6.9%), 4 cases with infectious mononucleosis (3.9%), 3 cases with exanthema subitum (2.9%).(4) After the therapy of rhG-CSF, significant improvement in clinical symptoms (fever returned, ease fatigue, mental improvement, etc.). And absolute value of leukocyte increased to (7.5±2.58)×109/L from (3.53±1.31)×109/L; absolute value of neutrophil increased to (3.28±1.82)×109/L from (1.05±0.48)×109/L; absolute value of leukocyte and neutrophil were significantly different before and after treatment.(5) After the therapy of rhG-CSF, curative effect was obvious, total effective rate was 89.2%.(6) Adverse reactions were rare, 2cases with rash (2%), 1 cases with gastrointestinal reaction (1%).Conclusion:(1) The result in lab showed that virus infection was the common factor leading to neutropenia(53.9%), followed by mycoplasma(27.5%), primary diseases often occurred in respiratory and digestive tract infections.(2) After the treatment of rhG-CSF, absolute value of leukocyte and neutrophil increased, curative effect was obvious.