Common Features Of Clinical In Study In Children With The Infection Related Neutropenia

BackgroundNeutropenia is a group of syndrome due to blood around neutrophils absolute count reduced. Neutrophils originated in the grain of department hematopoietic stem cells. Its life in blood cells is the shortest, and it is vulnerable to external environment and inner environmental impact. The incidence of neutropenia in children is not low. It is on the rise in recent years, receiving more and more attention. The reason of neutropenia is complex, most scholars distinguish it into congenital and acquired. The latter is in the majority. Acquired neutropenia can be caused by infection, immune, drug mediated, etc. In children acquired neutropenia disease are more common and infection is the most common reason, especially virus infection. Study found that neutropenia time and viremia appear time is consistent. The disease is mainly under the age of 3 in children and the young children have high incidence. Due to the attention of people, in recent years a lot of research about the disease are reported. Most of them are about the cause and the study on treatment. But the reported of analysis from the blood biochemical examination and immunology perspectives are seldom.This paper studies the 60 cases of children of infection related neutropenia. Study the clinical characteristics of the children in platelet, liver function, myocardial enzymes, cellular immune and humoral immune. Try to analysis the disease pathogenesis from immunolog perspectivey, and to provide theoretical basis for the immunotherapy of the disease.ObjectiveTo observe the etiology and age distribution feature of child patients with neutropenia. To summarize laboratory parameter characteristics (bone marrow cytology, platelet count, liver function, myocardial enzyme and immune function) and to further explore the pathogenesis from immunology perspectives of childhood neutropenia.MethodsSixty children diagnosed as acute neutropenia at Pediatric department of Shandong University Qilu Hospital between September 2008 and April 2010 were included in observation group and divided into two subgroups:infant observation group (aged between 1 month and 1 year old, n=37) and child observation group(aged between 1 year and 12 years old, n=23). At the same period, fifty-eight healthy children were selected into control group. Platelet count, alanine aminotransf erase (ALT) level, MB isoenzyme of creatine kinase(CK-MB), cellular and humoral immunity function were examined in both observation and control groups. SAS was used for all statistical analysis.Results(1) Patients younger than 1 year old make up 63.3% of the observation group. Infants aged between 6 months and 8 months constitute the largest part, accounting for 35.0% of all patients.(2)Bone marrow examinations showed hyperplasia or hypoplasia. Atypical lymphocytes were easy to see.(3) Statistically significant differences were found between different groups. Platelet count, ALT level, CK-MB level, IgM concentration and CD8+T cell ratio in infant observation group were higher than control group. IgG concentration, CD3+ T cell ratio, CD4+ T cell ratio and CD4+/CD8+ T cell ratio were lower in infant observation group than in control group. Platelet count, CK-MB level, IgM concentration, CD8+ T cell ratio in child observation group were higher than those in control group. In child observation group, IgG concentration, CD3+ T cell ratio, CD4+ T cell ratio and CD4+/CD8+ T cell ratio were lower than those in control group.ConclusionsChildhood neutropenia occured mostly in infants, Childhood neutropenia does not cause changes in platelet count, ALT level and CK-MB level. Cellular immunity disturbance after virus infection is a possible cause of childhood neutropenia.