Study On Bio-Impedance Gastric Motily Of Patient With Functional Dyspepsia

Objective1.To explore the clinical practicality of the detection of gastric motility by bio-impedance method.2.To investigate the effects on impedance gastrogram in patients of functional dyspepsia (FD) after treatment with domperidone.3.To explore the effect of prokinetics on FD.Methods1.The symptom scores were used to evaluate the changes of clinical symptom such as abdominal distention,early satiety, nausea ,vomiting, anorexy,abdominal pain, belching and heartburn.2.Wavelet transform and bio-impedance technique was used to evaluate gastric motility after treatment with domperidone. Some indexes such as frequency , signal power spectrum and dynamic spectrum, the power of impedance signal and electrical signal were collected.Results1.The feature of electrogastrogram of FD patients has recovered after treatment with Domperidone for 1 week, but parameter of impedance signal has not recovered yet.2.After 1 week treatment , Domperidone can significantly improve symptom scores of abdominal distention, abdominal pain, early satiety and belching(P<0.05).The patients with postprandial distress syndrome(PDS) improved significantly compared with epigastric pain syndrome (EPS)(P<0.05).The percentage of the power of dominant frequency of electrogastrogram before and after treatment was (52.07±7.01)% and (58.03±8.05)%, the difference was significant(P<0.05).There was no difference in the percentage of the power of the dominant frequency of impedance gastrogram with PDS and EPS patients before treatment(P>0.05); after Domperidone treatment, that was (46.50±4.08)% for PDS patients and (41.99±3.10)% for EPS patients, the difference was significant(P<0.01);the percentage of the whole frequency range had no change in both PDS and EPS groups(P>0.05).3.After 2 weeks treatment with Domperidone,the dominant frequency of impedance gastrogram of PDS group with abnormal gastric motility before and after treatment was (41.85±7.60)% and (49.01±5.41)%, the difference was significant(P<0.05);that was (46.31±2.33)% and (44.70±3.51)% of EPS group with abnormal gastric motility, the difference was significant(P>0.05).The percentage of the whole frequency range had no change in both PDS and EPS groups with normal gastric motility (P>0.05). Conclusion1.Wavelet transform and bio-impedance technique can be used to evaluate gastric motility situation corresponding gastrointestinal physiology and pathology conditions.2.The 1 week treatment with Domperidone can relieve clinical symptom, improve electrical signal,but not impedance gastric motility.The impedance gastric motility of PDS patients improved significantly after treatment with Domperidone compared with EPS patients. But there has no improvement on impedance gastric motility with PDS and EPS before and after treatment. The Rome III criteria had some degree of guiding significance in the treatment of FD.3.The 2 weeks treatment with Domperidone can improve impedance gastric motility of PDS patients with abnormal gastric motility, but not EPS patients with abnormal gastric motility. There has no improvement on both PDS and EPS patients with normal gastric motility. Not all of PDS patients need prokinetics.