Effects Of Arginine Enriched Enteral Nutrition On Nutritional Status, Cell Immunity And Safety Analysis Of Burned Patients

Objective:1.To investigate the effects of arginine enriched enteral nutrition on nutritional status,cell immunity of burned patients.2.To investigate the effects of arginine enriched enteral nutrition on blood routine examination,liver function ,renal function, blood-fasting sugar, blood fat and the incidence of gastrointestinal tract adverse reaction of burned patients.Methods:Random method was employed in the study. Thirty burned patients were randomly divided into enteral immune nutrition (EIN)group and enteral nutrition (EN) group, Sixteen patients in EIN group received enteral nutrition enriched with arginine, while the other14 patients in EN group received standard enteral nutrition . Nutritional support was continued for 14 days. Gastrointestinal tract reaction in 2 groups was observed. Venous blood on an empty stomach form patients of 2 groups was drawn before receiving nutrition treatment and on the morning of 7th ,14th day of treatment. Level of serum protein , subpopulations of T lymphocytes, blood routine examination, hepatic function parameters ,renal function parameters, blood-fasting sugar, serum lipide and gastrointestinal tract reaction in 2 groups was observed.Results:1.Compared with pre-treatment days[79.8±30.8 mg/L,1.7±0.4 g/L], level of prealbumin [265.3±111.7 mg/L] and transferrin [2.8±0.9 g/L]in serum of patients in 2 groups on post-treatment days significantly increased (P<0.05 or P<0.01),but there were no significant difference between 2 grouP on post-treatment days. The level of total serum protein on 14th day of treatment in 2 groups significantly increased, which form EIN group was significantly higher than that in EN group (P<0.05 ). The level of serum albumin of patients in EIN group on 7th and 14th day of treatment was significantly higher than that on pre-treatment days, however there was no significant changes in EN group.2. Cell percentages of CD4+,CD8+ on 14th day of treatment in EIN group was close to those on 14th per-treatment days. In EN group, cell percentages of CD4+ was significant decreased (P<0.05), while cell percentages of CD8+ was significantly increased (P<0.05). Cell percentages of CD4+ in EIN group was significantly higher than that in EN group. In both group, cell percentages of CD3+ were significantly higher than those on pre-treatment days(P<0.05). while there was no significant changes in the aspect of CD4+/CD8+ .3.The level of hemoglobin, red blood count and white blood count on 14th day of treatment in EIN group were significant decreased(P<0.05),while neutrophile granulocyte count and lymphocyte count were no significant changes. In EN group, there were no significant difference in each parameters of blood routine examination.4.There was no significant difference between before and after treatment in both group in the aspect of hepatic function ,renal function, blood-fasting sugar(P﹥0.05).5.In both group, most of parameters of serum lipide on 14th day of treatment were close to those on pre-treatment days.6.Incidence of gastrointestinal tract side effect in EIN group (25.0%) was close to that in EN group(P﹥0.05).Conclusions:1. Arginine enriched enteral nutrition can improve nutritiona status and stabilize cell immunity in severity burned patients validly.2.Arginine enriched enteral nutrition give little effect on blood routine examination, liver function ,renal function, blood-fasting sugar, blood fat in severity burned patients, and the incidence of gastrointestinal tract side effect was low, so arginine enriched enteral nutrition is a safe enteral nutrition preparation.