The Relationship Between Paraoxonase-1 Gene Polymorphism And The Lipids, The Location And The Size Of Hematoma In Cerebral Hemorrhage

Objective The aim of this study was to determine the relationship between the paroxonase (PON1) gene polymorphism and the lipids, the location and the size of hematoma in cerebral hemorrhage.Methods This was a case-control study, which enrolled 273 cases with cerebral hemorrhage (181 basal ganglia/internal capsule, 56 lobar, 24 brain stem and 12 cerebellum) and 271 healthy controls without congenital heart disease (CHD) and cerebrovascular disease (CVD). Polymerase chain reaction-restricted fragments length polymorphism was used to determine PON1 gene polymorphism.Results There was no significant difference in PON1 genotype and allele distribution between all cerebral hemorrhage patients and control group (P>0.05). The frequencies of Q and R is 36.9% and 63.1% in cerebral hemorrhage group, compared with the control group with 36.3%,63.7%, There was no significant difference(P>0.05) .the frequency of R is 29.3% in cerebellum, which is lower than 36.3% in control group. While the frequency of Q is higher than that in control group. However both of them showed no significant difference .The size of hematoma showed no significant difference among difference genotype in the same location of cerebral hemorrhage (P>0.05). And the blood lipids in different genotype and allele distribution also showed no significant difference. Conclusion: These results suggested that the PON1 gene polymorphism was not associated with the size of hematoma in cerebral hemorrhage. PON1 gene polymorphism was also not associated with the level of blood lipids.