Association Of Serum Insulin-like Growth Factor-1 And High Sensitive C Reactive Protein With Metabolic Syndrome

Objective:To explore the association of metabolic syndrome(MS) with fast serum insulin-like growth factor-1(IGF-1 ) and high-sensitive C reactive protein(hs-CRP) in patients with metabolic syndrome.Methods:The auther investigated,in a cross-sectional study,the fast serum insulin-like growth factor-1(IGF-1 ) and high-sensitive C reactive protein(hs-CRP) in 72 subjects.Enrollment of subjects took place during July to December 2008,in the Out-patient of XiangYa Hospital.Among them 45 had the MS(International Diabetes Federation definition,2005) and 27 did not,body weight,height,waist circumference,hip circumference,blood pressure,fasting Plasma glucose,lipid-profile and other clinical characteristics were collected,calculated body mass index(BMI),waist-to-hip ratio(WHR).The concentration of total serum insulin-like growth factor-1 and high-sensitivity C-reactive protein was measured by enzyme immunosorbent assay.Results:1.Compared with the control group,the fast serum IGF-1 level in the MS group was significantly lower(P＜0.05),and the concentration of hs-CRP was obviously higher(P＜0.01).2.Using Pearson's correlation analysis,the serum IGF-1 level was negatively related with hs-CRP(r=-0.387,P=0.001).3.Using Mutivariate logistic regression analysis,In the whole study population,expressed in terms of odds ratios(OR),①a person in the low tertile of IGF-1 had a 6.64 times excess risk of having the MS than a subject in the highest IGF-1 tertile(defined OR=1)(P＜0.05);②an individual in the high hs-CRP tertile had a 8.537 times greater risk of having MS than a subject in the lowest hs-CRP tertile(defined OR=1)(P＜0.01).③subjects with both low IGF-1(below the median)(defined OR=1) and high hs-CRP(in the highest tertile) had a 30.292-fold increased risk of having the metabolic syndrome(P＜0.01).Conclusion:patients with metabolic syndrome,the concentration of serum IGF-1 level decreases,and the serum hs-CRP concentration increases obviously,This suggests chronic inflammation;the serum IGF-1 level was negatively related with hs-CRP;low serum IGF-1 level and high hs-CRP concentration are increase an individual's risk of having the metabolic syndrome regardless of independ or combinantion,and combination maybe more effiective.